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Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Bosnakovski D, Toso EA, Ener ET, Gearhart MD, Yin L, Lüttmann FF, Magli A, Shi K, Kim J, Aihara H, Kyba M. Bosnakovski D, et al. iScience. 2023 Sep 2;26(10):107823. doi: 10.1016/j.isci.2023.107823. eCollection 2023 Oct 20. iScience. 2023. PMID: 37744032 Free PMC article.
DUXA, although transcriptionally inactive, has DNA binding overlap with DUX4, and DUXA-VP64 activates DUX4 targets and is cytotoxic. DUXA competition antagonizes the activity of DUX4 on its target genes, including in FSHD patient cells. ...
DUXA, although transcriptionally inactive, has DNA binding overlap with DUX4, and DUXA-VP64 activates DUX4 targets and is cyto …
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Bosnakovski D, Toso EA, Ener ET, Gearhart MD, Yin L, Lüttmann FF, Magli A, Shi K, Kim J, Aihara H, Kyba M. Bosnakovski D, et al. bioRxiv [Preprint]. 2023 Jan 22:2023.01.21.524976. doi: 10.1101/2023.01.21.524976. bioRxiv. 2023. PMID: 36711898 Free PMC article. Updated. Preprint.
DUXA competition antagonizes the activity of DUX4 on its target genes, including in FSHD patient cells. ...The DUX gene family therefore comprises cross-regulating members of opposing function, with implications for their roles in ZGA, FSHD, and cancer. HIGHLIGHTS: …
DUXA competition antagonizes the activity of DUX4 on its target genes, including in FSHD patient cells. ...The DUX gene family theref …
Relationship of DUX4 and target gene expression in FSHD myocytes.
Chau J, Kong X, Viet Nguyen N, Williams K, Ball M, Tawil R, Kiyono T, Mortazavi A, Yokomori K. Chau J, et al. Hum Mutat. 2021 Apr;42(4):421-433. doi: 10.1002/humu.24171. Epub 2021 Feb 4. Hum Mutat. 2021. PMID: 33502067 Free PMC article.
Interestingly, DUX4 and target gene expression become discordant later in differentiation with the increase of DUX4-positive/target gene-negative as well as DUX4-negative/target gene-positive myotubes. Depletion of DUX4-activated transcription factors, DUXA and LEUTX, spec …
Interestingly, DUX4 and target gene expression become discordant later in differentiation with the increase of DUX4-positive/target gene-neg …
Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype.
Preussner J, Zhong J, Sreenivasan K, Günther S, Engleitner T, Künne C, Glatzel M, Rad R, Looso M, Braun T, Kim J. Preussner J, et al. Cell Stem Cell. 2018 Dec 6;23(6):794-805.e4. doi: 10.1016/j.stem.2018.10.011. Epub 2018 Nov 15. Cell Stem Cell. 2018. PMID: 30449715 Free article.
The identity of tumor-initiating cells in many cancer types is unknown. Tumors often express genes associated with embryonic development, although the contributions of zygotic programs to tumor initiation and formation are poorly understood. ...We further found that Dux fa …
The identity of tumor-initiating cells in many cancer types is unknown. Tumors often express genes associated with embryonic developm …