Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2018 1
2021 1
2023 2
2024 1
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

5 results

Results by year

Filters applied: . Clear all
Page 1
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Bosnakovski D, Toso EA, Ener ET, Gearhart MD, Yin L, Lüttmann FF, Magli A, Shi K, Kim J, Aihara H, Kyba M. Bosnakovski D, et al. iScience. 2023 Sep 2;26(10):107823. doi: 10.1016/j.isci.2023.107823. eCollection 2023 Oct 20. iScience. 2023. PMID: 37744032 Free PMC article.
DUXA, although transcriptionally inactive, has DNA binding overlap with DUX4, and DUXA-VP64 activates DUX4 targets and is cytotoxic. DUXA competition antagonizes the activity of DUX4 on its target genes, including in FSHD patient cells. ...
DUXA, although transcriptionally inactive, has DNA binding overlap with DUX4, and DUXA-VP64 activates DUX4 targets and is cyto …
Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein.
Bosnakovski D, Toso EA, Ener ET, Gearhart MD, Yin L, Lüttmann FF, Magli A, Shi K, Kim J, Aihara H, Kyba M. Bosnakovski D, et al. bioRxiv [Preprint]. 2023 Jan 22:2023.01.21.524976. doi: 10.1101/2023.01.21.524976. bioRxiv. 2023. Update in: iScience. 2023 Sep 02;26(10):107823. doi: 10.1016/j.isci.2023.107823. PMID: 36711898 Free PMC article. Updated. Preprint.
DUXA competition antagonizes the activity of DUX4 on its target genes, including in FSHD patient cells. ...The DUX gene family therefore comprises cross-regulating members of opposing function, with implications for their roles in ZGA, FSHD, and cancer. HIGHLIGHTS: …
DUXA competition antagonizes the activity of DUX4 on its target genes, including in FSHD patient cells. ...The DUX gene family theref …
Relationship of DUX4 and target gene expression in FSHD myocytes.
Chau J, Kong X, Viet Nguyen N, Williams K, Ball M, Tawil R, Kiyono T, Mortazavi A, Yokomori K. Chau J, et al. Hum Mutat. 2021 Apr;42(4):421-433. doi: 10.1002/humu.24171. Epub 2021 Feb 4. Hum Mutat. 2021. PMID: 33502067 Free PMC article.
Depletion of DUX4-activated transcription factors, DUXA and LEUTX, specifically repressed a DUX4-target gene, KDM4E, later in differentiation, suggesting that after the initial activation by DUX4, target genes themselves contribute to the maintenance of downstream gene exp …
Depletion of DUX4-activated transcription factors, DUXA and LEUTX, specifically repressed a DUX4-target gene, KDM4E, later in differe …
Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype.
Preussner J, Zhong J, Sreenivasan K, Günther S, Engleitner T, Künne C, Glatzel M, Rad R, Looso M, Braun T, Kim J. Preussner J, et al. Cell Stem Cell. 2018 Dec 6;23(6):794-805.e4. doi: 10.1016/j.stem.2018.10.011. Epub 2018 Nov 15. Cell Stem Cell. 2018. PMID: 30449715 Free article.
The identity of tumor-initiating cells in many cancer types is unknown. Tumors often express genes associated with embryonic development, although the contributions of zygotic programs to tumor initiation and formation are poorly understood. ...We further found that Dux fa …
The identity of tumor-initiating cells in many cancer types is unknown. Tumors often express genes associated with embryonic developm …
A Genome-Wide Association Study and Rare Variant Analysis for Dupuytren Disease in a North American Population.
Grandizio LC, Smelser DT, Haley JS, Delma S, Klena JC, Carey DJ. Grandizio LC, et al. J Hand Surg Am. 2025 Feb;50(2):147-155. doi: 10.1016/j.jhsa.2024.10.001. Epub 2024 Nov 18. J Hand Surg Am. 2025. PMID: 39570219
Variant rs2122625 in EPDR1 also reached genome-wide significance. The RVA indicated that WNT7B, DUXA, LOXL1, CSMD2, and TACC2 were significantly associated with a diagnosis of DD. CONCLUSIONS: In our North American population, GWAS yielded variants in two genes that were s …
Variant rs2122625 in EPDR1 also reached genome-wide significance. The RVA indicated that WNT7B, DUXA, LOXL1, CSMD2, and TACC2 were si …