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DYNC1I1 Promotes the Proliferation and Migration of Gastric Cancer by Up-Regulating IL-6 Expression.
Gong LB, Wen T, Li Z, Xin X, Che XF, Wang J, Liu YP, Qu XJ. Gong LB, et al. Front Oncol. 2019 Jun 12;9:491. doi: 10.3389/fonc.2019.00491. eCollection 2019. Front Oncol. 2019. PMID: 31249807 Free PMC article.
DYNC1I1 promoted the proliferation and migration of gastric cancer cells both in vitro and in vivo. ...Collectively, these data revealed an important role for the DYNC1I1-driven IL-6/STAT pathway in gastric cancer proliferation and migration, suggestin …
DYNC1I1 promoted the proliferation and migration of gastric cancer cells both in vitro and in vivo. ...Collectively, these dat …
TNPO2 operates downstream of DYNC1I1 and promotes gastric cancer cell proliferation and inhibits apoptosis.
Gong L, Wen T, Li Z, Wang Y, Wang J, Che X, Liu Y, Qu X. Gong L, et al. Cancer Med. 2019 Dec;8(17):7299-7312. doi: 10.1002/cam4.2582. Epub 2019 Oct 11. Cancer Med. 2019. PMID: 31605449 Free PMC article.
The role of TNPO2 as a nonclassical nuclear import protein in tumors is limited. Our previous studies have shown that DYNC1I1 is a poor prognostic factor for gastric cancer and can promote the proliferation and metastasis of gastric cancer cells. ...At the sa …
The role of TNPO2 as a nonclassical nuclear import protein in tumors is limited. Our previous studies have shown that DYNC1I1 is a po …
DYNC1I1 acts as a promising prognostic biomarker and is correlated with immune infiltration in head and neck squamous cell carcinoma.
Ananya RG, Pandi C, Kannan B, Pandi A, Prasad P, Jayaseelan VP, Arumugam P. Ananya RG, et al. J Stomatol Oral Maxillofac Surg. 2023 Dec 10;125(4):101734. doi: 10.1016/j.jormas.2023.101734. Online ahead of print. J Stomatol Oral Maxillofac Surg. 2023. PMID: 38072235
BACKGROUND/PURPOSE: Dynein Cytoplasmic 1 Intermediate Chain 1 (DYNC1I1) is a crucial cytoplasmic dynein binding component, its high expression levels are associated with malignant progression and poor survival in different types of cancer; however, the oncogenic rol …
BACKGROUND/PURPOSE: Dynein Cytoplasmic 1 Intermediate Chain 1 (DYNC1I1) is a crucial cytoplasmic dynein binding component, its high e …
Localization of GPSM2 in the Nucleus of Invasive Breast Cancer Cells Indicates a Poor Prognosis.
Deng M, Zhang Z, Liu B, Hou K, Che X, Qu X, Liu Y, Hu X, Zhang Y, Lv Q. Deng M, et al. Front Oncol. 2020 Mar 3;10:227. doi: 10.3389/fonc.2020.00227. eCollection 2020. Front Oncol. 2020. PMID: 32195179 Free PMC article.
Importantly, patients with GPSM2 nuclear expression showed higher DYNC1I1 expression. Conclusion: GPSM2 was an independent prognostic factor in breast cancer and nuclear expression of GPSM2 was significantly associated with poor prognosis, which was related to the p …
Importantly, patients with GPSM2 nuclear expression showed higher DYNC1I1 expression. Conclusion: GPSM2 was an independent prognostic …
Bioinformatics analysis identifies DYNC1I1 as prognosis marker in male patients with liver hepatocellular carcinoma.
Zhou J, Zhu Y, Ma S, Li Y, Liu K, Xu S, Li X, Li L, Hu J, Liu Y. Zhou J, et al. PLoS One. 2021 Oct 22;16(10):e0258797. doi: 10.1371/journal.pone.0258797. eCollection 2021. PLoS One. 2021. PMID: 34679093 Free PMC article.
We predicted the interactions of these differentially expressed mRNAs, and used Cyto-Hubba to locate the hub gene-dynein cytoplasmic 1 intermediate chain 1 (DYNC1I1). RESULTS: Survival analysis showed that DYNC1I1 was a prognostic factor for LIHC male patients. ...C …
We predicted the interactions of these differentially expressed mRNAs, and used Cyto-Hubba to locate the hub gene-dynein cytoplasmic 1 inter …
CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway.
Liu YM, Cao Y, Zhao PS, Wu LY, Lu YM, Wang YL, Zhao JF, Liu XG. Liu YM, et al. Int J Biol Sci. 2022 Jan 1;18(2):637-651. doi: 10.7150/ijbs.66915. eCollection 2022. Int J Biol Sci. 2022. PMID: 35002514 Free PMC article.
Background: Circular RNAs (circRNAs), which generally act as microRNA (miRNA) sponges to competitively regulate the downstream target genes of miRNA, play an essential role in cancer biology. However, few studies have been reported on the role of circRNA based competitive …
Background: Circular RNAs (circRNAs), which generally act as microRNA (miRNA) sponges to competitively regulate the downstream target genes …
Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.
Neubauer HA, Tea MN, Zebol JR, Gliddon BL, Stefanidis C, Moretti PAB, Pitman MR, Costabile M, Kular J, Stringer BW, Day BW, Samuel MS, Bonder CS, Powell JA, Pitson SM. Neubauer HA, et al. Oncogene. 2019 Feb;38(8):1151-1165. doi: 10.1038/s41388-018-0504-9. Epub 2018 Sep 24. Oncogene. 2019. PMID: 30250299 Free PMC article.
Here, we report that SK2 interacts with the intermediate chain subunits of the retrograde-directed transport motor complex, cytoplasmic dynein 1 (DYNC1I1 and -2), and we show that this interaction, particularly with DYNC1I1, facilitates the transport of SK2 away fro …
Here, we report that SK2 interacts with the intermediate chain subunits of the retrograde-directed transport motor complex, cytoplasmic dyne …
Transcriptome hallmarks in Helicobacter pylori infection influence gastric cancer and MALT lymphoma.
Zhang J, Wei J, Wang Z, Feng Y, Wei Z, Hou X, Xu J, He Y, Yang D. Zhang J, et al. Epigenomics. 2020 Apr;12(8):661-671. doi: 10.2217/epi-2019-0152. Epub 2020 Mar 4. Epigenomics. 2020. PMID: 32129675
Aim: Altered long noncoding RNA (lncRNA) and mRNA is vital in the progression from Helicobacter pylori (H. pylori, HP) infection to gastric cancer (GC) and mucosa-associated lymphoid tissue (MALT) lymphoma. ...Results: Differentially expressed lncRNAs and mRNAs in both H. …
Aim: Altered long noncoding RNA (lncRNA) and mRNA is vital in the progression from Helicobacter pylori (H. pylori, HP) infection to gastric …
Detecting Prognosis Risk Biomarkers for Colon Cancer Through Multi-Omics-Based Prognostic Analysis and Target Regulation Simulation Modeling.
Yin Z, Yan X, Wang Q, Deng Z, Tang K, Cao Z, Qiu T. Yin Z, et al. Front Genet. 2020 May 26;11:524. doi: 10.3389/fgene.2020.00524. eCollection 2020. Front Genet. 2020. PMID: 32528533 Free PMC article.
BACKGROUND: Colon cancer is one of the most common health threats for humans since its high morbidity and mortality. ...Currently, although an integrated prognostic analysis of multi-omics for colon cancer is insufficient, it has been reported to be valuable for imp …
BACKGROUND: Colon cancer is one of the most common health threats for humans since its high morbidity and mortality. ...Currently, al …
19 results