Daanen JF - Search Results

1

Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.

Lin NH, Abreo MA, Gunn DE, Lebold SA, Lee EL, Wasicak JT, Hettinger AM, Daanen JF, Garvey DS, Campbell JE, Sullivan JP, Williams M, Arneric SP. Lin NH, et al. Among authors: daanen jf. Bioorg Med Chem Lett. 1999 Sep 20;9(18):2747-52. doi: 10.1016/s0960-894x(99)00462-x. Bioorg Med Chem Lett. 1999. PMID: 10509928

2

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.

Holladay MW, Bai H, Li Y, Lin NH, Daanen JF, Ryther KB, Wasicak JT, Kincaid JF, He Y, Hettinger AM, Huang P, Anderson DJ, Bannon AW, Buckley MJ, Campbell JE, Donnelly-Roberts DL, Gunther KL, Kim DJ, Kuntzweiler TA, Sullivan JP, Decker MW, Arneric SP. Holladay MW, et al. Among authors: daanen jf. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2797-802. doi: 10.1016/s0960-894x(98)00504-6. Bioorg Med Chem Lett. 1998. PMID: 9873625

3

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys.

Decker MW, Bannon AW, Curzon P, Gunther KL, Brioni JD, Holladay MW, Lin NH, Li Y, Daanen JF, Buccafusco JJ, Prendergast MA, Jackson WJ, Arneric SP. Decker MW, et al. Among authors: daanen jf. J Pharmacol Exp Ther. 1997 Oct;283(1):247-58. J Pharmacol Exp Ther. 1997. PMID: 9336330

4

Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.

Stewart AO, Cowart MD, Moreland RB, Latshaw SP, Matulenko MA, Bhatia PA, Wang X, Daanen JF, Nelson SL, Terranova MA, Namovic MT, Donnelly-Roberts DL, Miller LN, Nakane M, Sullivan JP, Brioni JD. Stewart AO, et al. Among authors: daanen jf. J Med Chem. 2004 Apr 22;47(9):2348-55. doi: 10.1021/jm0305669. J Med Chem. 2004. PMID: 15084133

5

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.

Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, Patel M, Kolasa T, Nakane M, Uchic ME, Miller LN, Terranova MA, Chang R, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Martino BR, Lynch JJ 3rd, Sullivan JP, Hsieh GC, Moreland RB, Brioni JD, Stewart AO. Cowart M, et al. Among authors: daanen jf. J Med Chem. 2004 Jul 15;47(15):3853-64. doi: 10.1021/jm030505a. J Med Chem. 2004. PMID: 15239663

6

Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.

Frost JM, Bunnelle WH, Tietje KR, Anderson DJ, Rueter LE, Curzon P, Surowy CS, Ji J, Daanen JF, Kohlhaas KL, Buckley MJ, Henry RF, Dyhring T, Ahring PK, Meyer MD. Frost JM, et al. Among authors: daanen jf. J Med Chem. 2006 Dec 28;49(26):7843-53. doi: 10.1021/jm060846z. J Med Chem. 2006. PMID: 17181167

7

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.

Zheng GZ, Bhatia P, Daanen J, Kolasa T, Patel M, Latshaw S, El Kouhen OF, Chang R, Uchic ME, Miller L, Nakane M, Lehto SG, Honore MP, Moreland RB, Brioni JD, Stewart AO. Zheng GZ, et al. J Med Chem. 2005 Nov 17;48(23):7374-88. doi: 10.1021/jm0504407. J Med Chem. 2005. PMID: 16279797

8

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.

Wang X, Bhatia PA, Daanen JF, Latsaw SP, Rohde J, Kolasa T, Hakeem AA, Matulenko MA, Nakane M, Uchic ME, Miller LN, Chang R, Moreland RB, Brioni JD, Stewart AO. Wang X, et al. Among authors: daanen jf. Bioorg Med Chem. 2005 Aug 1;13(15):4667-78. doi: 10.1016/j.bmc.2005.04.060. Bioorg Med Chem. 2005. PMID: 15896964

9

Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.

Bunnelle WH, Daanen JF, Ryther KB, Schrimpf MR, Dart MJ, Gelain A, Meyer MD, Frost JM, Anderson DJ, Buckley M, Curzon P, Cao YJ, Puttfarcken P, Searle X, Ji J, Putman CB, Surowy C, Toma L, Barlocco D. Bunnelle WH, et al. Among authors: daanen jf. J Med Chem. 2007 Jul 26;50(15):3627-44. doi: 10.1021/jm070018l. Epub 2007 Jun 22. J Med Chem. 2007. PMID: 17585748

10

Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.

Lee CH, Daanen JF, Jiang M, Yu H, Kohlhaas KL, Alexander K, Jarvis MF, Kowaluk EL, Bhagwat SS. Lee CH, et al. Among authors: daanen jf. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2419-22. doi: 10.1016/s0960-894x(01)00454-1. Bioorg Med Chem Lett. 2001. PMID: 11549437

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