Role of phenoxyl radicals in DNA adduction by chlorophenol xenobiotics following peroxidase activation.
Dai J, Sloat AL, Wright MW, Manderville RA.
Dai J, et al.
Chem Res Toxicol. 2005 Apr;18(4):771-9. doi: 10.1021/tx0500023.
Chem Res Toxicol. 2005.
PMID: 15833038
Recently, we characterized the ability of pentachlorophenol (PCP) to react covalently with deoxyguanosine (dG) following treatment with horseradish peroxidase (HRP)/H2O2 or myeloperoxidase to yield a C8-dG oxygen (O)-adduct that suggested the intermediacy of the pentachlorophenox …
Recently, we characterized the ability of pentachlorophenol (PCP) to react covalently with deoxyguanosine (dG) following treatment with hors …