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DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.
Lentini JM, Alsaif HS, Faqeih E, Alkuraya FS, Fu D. Lentini JM, et al. Nat Commun. 2020 May 19;11(1):2510. doi: 10.1038/s41467-020-16321-6. Nat Commun. 2020. PMID: 32427860 Free PMC article.
DALRD3-deficient human cells exhibit nearly complete loss of the m3C modification in tRNA-Arg species. ...These findings uncover an unexpected function for the DALRD3 protein in the targeting of distinct arginine tRNAs for m3C modification and suggest a crucial biol …
DALRD3-deficient human cells exhibit nearly complete loss of the m3C modification in tRNA-Arg species. ...These findings uncover an u …
Molecular neuroanatomy of anorexia nervosa.
Howard D, Negraes P, Voineskos AN, Kaplan AS, Muotri AR, Duvvuri V, French L. Howard D, et al. Sci Rep. 2020 Jul 10;10(1):11411. doi: 10.1038/s41598-020-67692-1. Sci Rep. 2020. PMID: 32651428 Free PMC article.
Motivated by enrichment of these feeding circuits, we tested if these genes respond to fasting in mice hypothalami, which highlighted the differential expression of Rps26 and Dalrd3. This work improves our understanding of the neurobiology of anorexia nervosa by suggesting …
Motivated by enrichment of these feeding circuits, we tested if these genes respond to fasting in mice hypothalami, which highlighted the di …
Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci.
Strom NI, Gerring ZF, Galimberti M, Yu D, Halvorsen MW, Abdellaoui A, Rodriguez-Fontenla C, Sealock JM, Bigdeli T, Coleman JR, Mahjani B, Thorp JG, Bey K, Burton CL, Luykx JJ, Zai G, Alemany S, Andre C, Askland KD, Banaj N, Barlassina C, Nissen JB, Bienvenu OJ, Black D, Bloch MH, Boberg J, Børte S, Bosch R, Breen M, Brennan BP, Brentani H, Buxbaum JD, Bybjerg-Grauholm J, Byrne EM, Cabana-Dominguez J, Camarena B, Camarena A, Cappi C, Carracedo A, Casas M, Cavallini MC, Ciullo V, Cook EH, Crosby J, Cullen BA, De Schipper EJ, Delorme R, Djurovic S, Elias JA, Estivill X, Falkenstein MJ, Fundin BT, Garner L, German C, Gironda C, Goes FS, Grados MA, Grove J, Guo W, Haavik J, Hagen K, Harrington K, Havdahl A, Höffler KD, Hounie AG, Hucks D, Hultman C, Janecka M, Jenike E, Karlsson EK, Kelley K, Klawohn J, Krasnow JE, Krebs K, Lange C, Lanzagorta N, Levey D, Lindblad-Toh K, Macciardi F, Maher B, Mathes B, McArthur E, McGregor N, McLaughlin NC, Meier S, Miguel EC, Mulhern M, Nestadt PS, Nurmi EL, O'Connell KS, Osiecki L, Ousdal OT, Palviainen T, Pedersen NL, Piras F, Piras F, Potluri S, Rabionet R, Ramirez A, Rauch S, Reichenberg A, Riddle MA, Ripke S, Rosário MC, Sampaio AS, Schiele MA, S… See abstract for full author list ➔ Strom NI, et al. medRxiv [Preprint]. 2024 Mar 13:2024.03.13.24304161. doi: 10.1101/2024.03.13.24304161. medRxiv. 2024. PMID: 38712091 Free PMC article. Preprint.
Functional and positional QTL gene-based approaches identified 249 significant candidate risk genes for OCD, of which 25 were identified as putatively causal, highlighting WDR6, DALRD3, CTNND1 and genes in the MHC region. Tissue and single-cell enrichment analyses highligh …
Functional and positional QTL gene-based approaches identified 249 significant candidate risk genes for OCD, of which 25 were identified as …
Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status.
Di Leva G, Piovan C, Gasparini P, Ngankeu A, Taccioli C, Briskin D, Cheung DG, Bolon B, Anderlucci L, Alder H, Nuovo G, Li M, Iorio MV, Galasso M, Santhanam R, Marcucci G, Perrotti D, Powell KA, Bratasz A, Garofalo M, Nephew KP, Croce CM. Di Leva G, et al. PLoS Genet. 2013;9(3):e1003311. doi: 10.1371/journal.pgen.1003311. Epub 2013 Mar 7. PLoS Genet. 2013. PMID: 23505378 Free PMC article.
Here, we established that the miR-191/425 cluster is transcriptionally dependent on the host gene, DALRD3, and that the hormone 17beta-estradiol (estrogen or E2) controls expression of both miR-191/425 and DALRD3. MiR-191/425 locus characterization revealed that the …
Here, we established that the miR-191/425 cluster is transcriptionally dependent on the host gene, DALRD3, and that the hormone 17bet …
Integrative genomics analysis identifies five promising genes implicated in insomnia risk based on multiple omics datasets.
Sun H, Zhang J, Ma Y, Liu J. Sun H, et al. Biosci Rep. 2020 Sep 30;40(9):BSR20201084. doi: 10.1042/BSR20201084. Biosci Rep. 2020. PMID: 32830860 Free PMC article.
Through a PPI network analysis, we found that there existed highly functional interactions among these five identified genes. Three genes of LDHA (P=0.044), DALRD3 (P=5.0 10-5), and HEBP2 (P=0.032) showed significantly lower expression level in brain tissues of insomnic pa …
Through a PPI network analysis, we found that there existed highly functional interactions among these five identified genes. Three genes of …
Identification of key genes and biological pathways associated with vascular aging in diabetes based on bioinformatics and machine learning.
Wang S, Wang X, Chen J, Wang M, Zhang C. Wang S, et al. Aging (Albany NY). 2024 May 27;16. doi: 10.18632/aging.205870. Online ahead of print. Aging (Albany NY). 2024. PMID: 38809515 Free article.
Machine learning algorithms, including LASSO regression and SVM-RFE, pinpointed six key genes: TFB1M, FOXRED2, LY75, DALRD3, PI4K2B, and NDOR1. Immune cell infiltration analysis demonstrated correlations between diabetic vascular aging, the identified key genes, and infilt …
Machine learning algorithms, including LASSO regression and SVM-RFE, pinpointed six key genes: TFB1M, FOXRED2, LY75, DALRD3, PI4K2B, …
Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns.
Grinchuk OV, Jenjaroenpun P, Orlov YL, Zhou J, Kuznetsov VA. Grinchuk OV, et al. Nucleic Acids Res. 2010 Jan;38(2):534-47. doi: 10.1093/nar/gkp954. Epub 2009 Nov 11. Nucleic Acids Res. 2010. PMID: 19906709 Free PMC article.
Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 tran …
Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and …