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Page 1
DAND5 Inactivation Enhances Cardiac Differentiation in Mouse Embryonic Stem Cells.
Inácio JM, von Gilsa Lopes J, Silva AM, Cristo F, Marques S, Futschik ME, Belo JA. Inácio JM, et al. Front Cell Dev Biol. 2021 Apr 13;9:629430. doi: 10.3389/fcell.2021.629430. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 33928078 Free PMC article.
Dand5 loss-of-function generated the double of cardiac beating foci compared to the wild-type cells. The early formation of cardiac progenitor cells and the increased proliferative capacity of Dand5 KO mESC-derived cardiomyocytes contribute to the observed higher nu …
Dand5 loss-of-function generated the double of cardiac beating foci compared to the wild-type cells. The early formation of cardiac p …
Dand5 is involved in zebrafish tailbud cell movement.
Bota C, Martins GG, Lopes SS. Bota C, et al. Front Cell Dev Biol. 2023 Jan 9;10:989615. doi: 10.3389/fcell.2022.989615. eCollection 2022. Front Cell Dev Biol. 2023. PMID: 36699016 Free PMC article.
Cell exit from the posterior cluster became bilaterally synchronous in dand5-/- mutants. Our study revealed a new link between somite specification and Dand5 function. The gene dand5 is well known as the first asymmetric gene involved in vertebrate LR develop …
Cell exit from the posterior cluster became bilaterally synchronous in dand5-/- mutants. Our study revealed a new link between somite …
COCO/DAND5 inhibits developmental and pathological ocular angiogenesis.
Popovic N, Hooker E, Barabino A, Flamier A, Provost F, Buscarlet M, Bernier G, Larrivée B. Popovic N, et al. EMBO Mol Med. 2021 Mar 5;13(3):e12005. doi: 10.15252/emmm.202012005. Epub 2021 Feb 15. EMBO Mol Med. 2021. PMID: 33587337 Free PMC article.
Depletion of DAND5 Hinders EMT in Mouse Embryonic Stem Cell Differentiation.
von Gilsa Lopes J, Inácio JM, Marques S, Añez SB, Belo JA. von Gilsa Lopes J, et al. Curr Stem Cell Res Ther. 2023 May 16. doi: 10.2174/1574888X18666230516154113. Online ahead of print. Curr Stem Cell Res Ther. 2023. PMID: 37194232
BACKGROUND: Dand5 encodes a protein that acts as an antagonist to Nodal/TGF-beta and Wnt pathways. ...OBJECTIVE: This study aimed to investigate the molecular mechanisms affected by the depletion of Dand5. METHODS: DAND5-KO and wild-type embryoid bodies (EBs) …
BACKGROUND: Dand5 encodes a protein that acts as an antagonist to Nodal/TGF-beta and Wnt pathways. ...OBJECTIVE: This study aimed to …
A novel biallelic loss-of-function variant in DAND5 causes heterotaxy syndrome.
Ganapathi M, Buchovecky CM, Cristo F, Ahimaz P, Ruzal-Shapiro C, Wou K, Inácio JM, Iglesias A, Belo JA, Jobanputra V. Ganapathi M, et al. Cold Spring Harb Mol Case Stud. 2022 Dec 28;8(7):a006248. doi: 10.1101/mcs.a006248. Print 2022 Dec. Cold Spring Harb Mol Case Stud. 2022. PMID: 36316122 Free PMC article.
Recently, the first case was reported of a DAND5 biallelic loss-of-function (LoF) variant in an individual with heterotaxy. ...This work strengthens the genetic and functional evidence for biallelic LoF variants in DAND5 causing an autosomal recessive heterotaxy syn …
Recently, the first case was reported of a DAND5 biallelic loss-of-function (LoF) variant in an individual with heterotaxy. ...This w …
The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer.
Chi Y, Yao L, Hu X, Huang S, Huang N, Li S, Shao Z, Wu J. Chi Y, et al. Oncotarget. 2016 Mar 22;7(12):14951-62. doi: 10.18632/oncotarget.7498. Oncotarget. 2016. PMID: 26908452 Free PMC article.
Improvements in timely and effective diagnosis and prediction are needed. As reported, secreted DAND5 is contributed to BC metastasis. We aim to assess whether DAND5 in peripheral blood serum could determine BC-specific mortality. ...Furthermore, secreted DAND5 …
Improvements in timely and effective diagnosis and prediction are needed. As reported, secreted DAND5 is contributed to BC metastasis …
Immotile cilia mechanically sense the direction of fluid flow for left-right determination.
Katoh TA, Omori T, Mizuno K, Sai X, Minegishi K, Ikawa Y, Nishimura H, Itabashi T, Kajikawa E, Hiver S, Iwane AH, Ishikawa T, Okada Y, Nishizaka T, Hamada H. Katoh TA, et al. Science. 2023 Jan 6;379(6627):66-71. doi: 10.1126/science.abq8148. Epub 2023 Jan 5. Science. 2023. PMID: 36603091
Application of mechanical stimuli to immotile cilia by optical tweezers induced calcium ion transients and degradation of Dand5 messenger RNA (mRNA) in the targeted cells. The Pkd2 channel protein was preferentially localized to the dorsal side of immotile cilia, and calci …
Application of mechanical stimuli to immotile cilia by optical tweezers induced calcium ion transients and degradation of Dand5 messe …
Elevated serum DAND5 is associated with metastasis and predicts poor prognosis in colorectal cancer.
Miao X, Zhang Y, Sun J, Cui S, Meng Q, Zhu K, Hu X, Wang T. Miao X, et al. United European Gastroenterol J. 2017 Aug;5(5):725-734. doi: 10.1177/2050640616674838. Epub 2016 Oct 12. United European Gastroenterol J. 2017. PMID: 28815037 Free PMC article.
METHODS: The role of DAND5 was explored in CRC cells and clinical significance of DAND5 was investigated in CRC patients (n = 217) and healthy controls (n = 63). ...A significant positive correlation existed between serum DAND5 levels and matched DAND5 …
METHODS: The role of DAND5 was explored in CRC cells and clinical significance of DAND5 was investigated in CRC patients (n = …
Gene-Edited Human-Induced Pluripotent Stem Cell Lines to Elucidate DAND5 Function throughout Cardiac Differentiation.
Inácio JM, Nunes MM, Almeida M, Cristo F, Anjos R, Belo JA. Inácio JM, et al. Cells. 2023 Feb 5;12(4):520. doi: 10.3390/cells12040520. Cells. 2023. PMID: 36831187 Free PMC article.
Here, we applied a disease model using human-induced pluripotent stem cells (hiPSCs) to evaluate the function of DAND5 on human cardiomyocyte (CM) differentiation and proliferation. (2) Methods: Taking advantage of our DAND5 patient-derived iPSC line, we used CRISPR …
Here, we applied a disease model using human-induced pluripotent stem cells (hiPSCs) to evaluate the function of DAND5 on human cardi …
Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5.
Maerker M, Getwan M, Dowdle ME, McSheene JC, Gonzalez V, Pelliccia JL, Hamilton DS, Yartseva V, Vejnar C, Tingler M, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Blum M, Schweickert A. Maerker M, et al. Nat Commun. 2021 Sep 16;12(1):5482. doi: 10.1038/s41467-021-25464-z. Nat Commun. 2021. PMID: 34531379 Free PMC article.
To repress dand5, Bicc1 co-operates with Dicer1, placing both proteins in the process of flow sensing. Intriguingly, Bicc1 mediated translational repression of a dand5 3'-UTR mRNA reporter was responsive to pkd2, suggesting that a flow induced Pkd2 signal triggers B …
To repress dand5, Bicc1 co-operates with Dicer1, placing both proteins in the process of flow sensing. Intriguingly, Bicc1 mediated t …
57 results