Dantzig AH - Search Results

1

Pharmacogenomics of gemcitabine metabolism: functional analysis of genetic variants in cytidine deaminase and deoxycytidine kinase.

Baker JA, Wickremsinhe ER, Li CH, Oluyedun OA, Dantzig AH, Hall SD, Qian YW, Ring BJ, Wrighton SA, Guo Y. Baker JA, et al. Among authors: dantzig ah. Drug Metab Dispos. 2013 Mar;41(3):541-5. doi: 10.1124/dmd.112.048769. Epub 2012 Dec 10. Drug Metab Dispos. 2013. PMID: 23230131

2

Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.

Pratt SE, Durland-Busbice S, Shepard RL, Donoho GP, Starling JJ, Wickremsinhe ER, Perkins EJ, Dantzig AH. Pratt SE, et al. Among authors: dantzig ah. Mol Cancer Ther. 2013 Apr;12(4):481-90. doi: 10.1158/1535-7163.MCT-12-0654. Epub 2013 Jan 31. Mol Cancer Ther. 2013. PMID: 23371859

3

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.

Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA. Ekins S, et al. Among authors: dantzig ah. Mol Pharmacol. 2002 May;61(5):974-81. doi: 10.1124/mol.61.5.974. Mol Pharmacol. 2002. PMID: 11961114

4

Evaluation of an in vitro coculture model for the blood-brain barrier: comparison of human umbilical vein endothelial cells (ECV304) and rat glioma cells (C6) from two commercial sources.

Scism JL, Laska DA, Horn JW, Gimple JL, Pratt SE, Shepard RL, Dantzig AH, Wrighton SA. Scism JL, et al. Among authors: dantzig ah. In Vitro Cell Dev Biol Anim. 1999 Nov-Dec;35(10):580-92. doi: 10.1007/s11626-999-0096-3. In Vitro Cell Dev Biol Anim. 1999. PMID: 10614867

5

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.

Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, Yasuda K, Shepard RL, Winter MA, Schuetz JD, Wikel JH, Wrighton SA. Ekins S, et al. Among authors: dantzig ah. Mol Pharmacol. 2002 May;61(5):964-73. doi: 10.1124/mol.61.5.964. Mol Pharmacol. 2002. PMID: 11961113

6

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.

Dantzig AH, Shepard RL, Law KL, Tabas L, Pratt S, Gillespie JS, Binkley SN, Kuhfeld MT, Starling JJ, Wrighton SA. Dantzig AH, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):854-62. J Pharmacol Exp Ther. 1999. PMID: 10411602

7

Synthesis, crystallization, and biological evaluation of an orally active prodrug of gemcitabine.

Bender DM, Bao J, Dantzig AH, Diseroad WD, Law KL, Magnus NA, Peterson JA, Perkins EJ, Pu YJ, Reutzel-Edens SM, Remick DM, Starling JJ, Stephenson GA, Vaid RK, Zhang D, McCarthy JR. Bender DM, et al. Among authors: dantzig ah. J Med Chem. 2009 Nov 26;52(22):6958-61. doi: 10.1021/jm901181h. J Med Chem. 2009. PMID: 19860433

8

Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.

Pratt SE, Durland-Busbice S, Shepard RL, Heinz-Taheny K, Iversen PW, Dantzig AH. Pratt SE, et al. Among authors: dantzig ah. Clin Cancer Res. 2013 Mar 1;19(5):1159-68. doi: 10.1158/1078-0432.CCR-12-1184. Epub 2013 Jan 16. Clin Cancer Res. 2013. PMID: 23325581

9

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.

Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH. Pratt S, et al. Among authors: dantzig ah. Mol Cancer Ther. 2005 May;4(5):855-63. doi: 10.1158/1535-7163.MCT-04-0291. Mol Cancer Ther. 2005. PMID: 15897250

10

Low-dose metronomic oral dosing of a prodrug of gemcitabine (LY2334737) causes antitumor effects in the absence of inhibition of systemic vasculogenesis.

Francia G, Shaked Y, Hashimoto K, Sun J, Yin M, Cesta C, Xu P, Man S, Hackl C, Stewart J, Uhlik M, Dantzig AH, Foster FS, Kerbel RS. Francia G, et al. Among authors: dantzig ah. Mol Cancer Ther. 2012 Mar;11(3):680-9. doi: 10.1158/1535-7163.MCT-11-0659. Epub 2011 Dec 21. Mol Cancer Ther. 2012. PMID: 22188817 Free PMC article.

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