Darke PL - Search Results

1

HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins.

Darke PL, Nutt RF, Brady SF, Garsky VM, Ciccarone TM, Leu CT, Lumma PK, Freidinger RM, Veber DF, Sigal IS. Darke PL, et al. Biochem Biophys Res Commun. 1988 Oct 14;156(1):297-303. doi: 10.1016/s0006-291x(88)80839-8. Biochem Biophys Res Commun. 1988. PMID: 3052448

2

Human immunodeficiency virus protease. Bacterial expression and characterization of the purified aspartic protease.

Darke PL, Leu CT, Davis LJ, Heimbach JC, Diehl RE, Hill WS, Dixon RA, Sigal IS. Darke PL, et al. J Biol Chem. 1989 Feb 5;264(4):2307-12. J Biol Chem. 1989. PMID: 2644259 Free article.

3

Affinity purification of the HIV-1 protease.

Heimbach JC, Garsky VM, Michelson SR, Dixon RA, Sigal IS, Darke PL. Heimbach JC, et al. Among authors: darke pl. Biochem Biophys Res Commun. 1989 Nov 15;164(3):955-60. doi: 10.1016/0006-291x(89)91762-2. Biochem Biophys Res Commun. 1989. PMID: 2686642

4

Chemical synthesis and enzymatic activity of a 99-residue peptide with a sequence proposed for the human immunodeficiency virus protease.

Nutt RF, Brady SF, Darke PL, Ciccarone TM, Colton CD, Nutt EM, Rodkey JA, Bennett CD, Waxman LH, Sigal IS, et al. Nutt RF, et al. Among authors: darke pl. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7129-33. doi: 10.1073/pnas.85.19.7129. Proc Natl Acad Sci U S A. 1988. PMID: 3050988 Free PMC article.

5

Interaction of mutant forms of the HIV-1 protease with substrate and inhibitors.

Darke PL, Kohl NE, Hanobik MG, Leu CT, Vacca JP, Guare JP, Heimbach JC, Dixon RA. Darke PL, et al. Adv Exp Med Biol. 1991;306:483-7. doi: 10.1007/978-1-4684-6012-4_61. Adv Exp Med Biol. 1991. PMID: 1812746 No abstract available.

6

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al. deSolms SJ, et al. Among authors: darke pl. J Med Chem. 1991 Sep;34(9):2852-7. doi: 10.1021/jm00113a025. J Med Chem. 1991. PMID: 1910089

7

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

Vacca JP, Guare JP, deSolms SJ, Sanders WM, Giuliani EA, Young SD, Darke PL, Zugay J, Sigal IS, Schleif WA, et al. Vacca JP, et al. Among authors: darke pl. J Med Chem. 1991 Mar;34(3):1225-8. doi: 10.1021/jm00107a050. J Med Chem. 1991. PMID: 2002465 No abstract available.

8

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1.

Navia MA, Fitzgerald PM, McKeever BM, Leu CT, Heimbach JC, Herber WK, Sigal IS, Darke PL, Springer JP. Navia MA, et al. Among authors: darke pl. Nature. 1989 Feb 16;337(6208):615-20. doi: 10.1038/337615a0. Nature. 1989. PMID: 2645523

9

Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.

Fitzgerald PM, McKeever BM, VanMiddlesworth JF, Springer JP, Heimbach JC, Leu CT, Herber WK, Dixon RA, Darke PL. Fitzgerald PM, et al. Among authors: darke pl. J Biol Chem. 1990 Aug 25;265(24):14209-19. J Biol Chem. 1990. PMID: 2201682 Free article.

10

Crystallization of the aspartylprotease from the human immunodeficiency virus, HIV-1.

McKeever BM, Navia MA, Fitzgerald PM, Springer JP, Leu CT, Heimbach JC, Herbert WK, Sigal IS, Darke PL. McKeever BM, et al. Among authors: darke pl. J Biol Chem. 1989 Feb 5;264(4):1919-21. J Biol Chem. 1989. PMID: 2644246 Free article.

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