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Crystalline ruthenium polypyridine nanoparticles: a targeted treatment of bacterial infection with multifunctional antibacterial, adhesion and surface-anchoring photosensitizer properties.
Yin C, Wang Z, Ding X, Chen X, Wang J, Yang E, Wang W, Martin LL, Sun D. Yin C, et al. J Mater Chem B. 2021 May 12;9(18):3808-3825. doi: 10.1039/d1tb00103e. J Mater Chem B. 2021. PMID: 33979422
However, many of these antibacterial materials are less effective towards bacteria than traditional drugs, either due to poor specificity or antibacterial activity. This can result in needless and excessive drug use in treatments. This paper describes a multifunctio …
However, many of these antibacterial materials are less effective towards bacteria than traditional drugs, either due to poor specifi …
Silver(I)-N-heterocyclic carbene complexes challenge cancer; evaluation of their anticancer properties and in silico studies.
Şahin-Bölükbaşı S, Cantürk-Kılıçkaya P, Kılıçkaya O. Şahin-Bölükbaşı S, et al. Drug Dev Res. 2021 May 12. doi: 10.1002/ddr.21822. Online ahead of print. Drug Dev Res. 2021. PMID: 33978961 Review.
Because of the continuous need for efficient therapeutic agents against various kinds of cancers and infectious diseases, the pharmaceutical industry has to find new candidates and strategies to develop novel and efficient drugs. They increasingly use computational …
Because of the continuous need for efficient therapeutic agents against various kinds of cancers and infectious diseases, the pharmaceuti
(34)S-SIL of PCSK9-Active Oligonucleotide as Tools for Accurate Quantification by Mass Spectrometry.
Stulz R, Milligan F, Stovold C, Love I, Strömberg R, Andersson S, Dahlén A. Stulz R, et al. Nucleic Acid Ther. 2021 May 11. doi: 10.1089/nat.2020.0915. Online ahead of print. Nucleic Acid Ther. 2021. PMID: 33978476
Stable isotope labeling (SIL) of active pharmaceutical ingredients (API) is a well-established technique for the accurate quantification of small-molecule drugs. As the scope of active ingredients is expanding into areas of larger molecules, such as oligonucleotides …
Stable isotope labeling (SIL) of active pharmaceutical ingredients (API) is a well-established technique for the accurate quantificat …
Analysis of the Effect of N555 Mutations on the Product Specificity of Dextransucrase Using Caffeic Acid Phenethyl Ester as an Acceptor Substrate.
Yu XQ, Yang JW, Ding XJ, Liu LH, Hu XQ, Zhang HB. Yu XQ, et al. J Agric Food Chem. 2021 May 12. doi: 10.1021/acs.jafc.1c00822. Online ahead of print. J Agric Food Chem. 2021. PMID: 33978404
Bioglycosylation is an efficient strategy to improve biological activities and physicochemical properties of natural compounds to develop structural modifications of drugs. In this study, an N555 residue was identified as a candidate for site-directed mutagenesis through s …
Bioglycosylation is an efficient strategy to improve biological activities and physicochemical properties of natural compounds to develop st …
An update on emerging therapeutics to combat COVID-19.
Shah NN, Nabi SU, Bashir SM, Rather MA, Kalwar Q, Ali SI, Sheikh WM, Ganai A. Shah NN, et al. Basic Clin Pharmacol Toxicol. 2021 May 11. doi: 10.1111/bcpt.13600. Online ahead of print. Basic Clin Pharmacol Toxicol. 2021. PMID: 33977663 Review.
These studies have also revealed potential targets for drug development and drug repurposing against COVID-19. Clinical trials utilizing antiviral drugs and other drugs have given inconclusive results regarding their clinical efficacy and side effects. …
These studies have also revealed potential targets for drug development and drug repurposing against COVID-19. Clinical trials …
Ultra-Conformable Ionic Skin with Multi-Modal Sensing, Broad-Spectrum Antimicrobial and Regenerative Capabilities for Smart and Expedited Wound Care.
Lin X, Mao Y, Li P, Bai Y, Chen T, Wu K, Chen D, Yang H, Yang L. Lin X, et al. Adv Sci (Weinh). 2021 Feb 15;8(9):2004627. doi: 10.1002/advs.202004627. eCollection 2021 May. Adv Sci (Weinh). 2021. PMID: 33977071 Free PMC article.
The base of MiS is a unique skin-like, conductive and self-adaptive adhesive polyacrylamide/starch double-network hydrogel (PSH) and self-powered, flexible, triboelectric sensor(s) is integrated on top of PSH for multi-tactile sensing. MiS could enhance wound contraction, …
The base of MiS is a unique skin-like, conductive and self-adaptive adhesive polyacrylamide/starch double-network hydrogel (PSH) and self-po …
Mechanisms and detection methods of Mycobacterium tuberculosis rifampicin resistance: The phenomenon of drug resistance is complex.
Xu G, Liu H, Jia X, Wang X, Xu P. Xu G, et al. Tuberculosis (Edinb). 2021 May 8;128:102083. doi: 10.1016/j.tube.2021.102083. Online ahead of print. Tuberculosis (Edinb). 2021. PMID: 33975262 Review.
Compared with other drugs resistance, the RIF-R mechanism of Mycobacterium tuberculosis (M. tuberculosis) is one of the clearest, which is mainly caused by RIF resistance-related mutations in the rpoB gene. ...Besides the mutations in rpoB, M. tuberculosis can decre …
Compared with other drugs resistance, the RIF-R mechanism of Mycobacterium tuberculosis (M. tuberculosis) is one of the cleare …
Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy.
Cheng X, Xu HD, Ran HH, Liang G, Wu FG. Cheng X, et al. ACS Nano. 2021 May 11. doi: 10.1021/acsnano.1c00498. Online ahead of print. ACS Nano. 2021. PMID: 33974797
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which inevitably affects the drugs' therapeutic outcomes. ...
Cancer cells frequently exhibit resistance to various molecular and nanoscale drugs, which inevitably affects the drugs' thera …
QSAR analysis of 3-pyrimidin-4-yl-oxazolidin-2-one derivatives isocitrate dehydrogenase inhibitors using Topomer CoMFA and HQSAR methods.
Tong JB, Bian S, Zhang X, Luo D. Tong JB, et al. Mol Divers. 2021 May 11. doi: 10.1007/s11030-021-10222-6. Online ahead of print. Mol Divers. 2021. PMID: 33974175
Ten new drug molecules have been designed using Topomer search technology. ...Newly designed molecules after docking with corresponding proteins in the PDB library, it can explore the targets of drug molecules acting with large proteins and the related force, which …
Ten new drug molecules have been designed using Topomer search technology. ...Newly designed molecules after docking with correspondi …
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