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Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.
Darios F, Wasser C, Shakirzyanova A, Giniatullin A, Goodman K, Munoz-Bravo JL, Raingo J, Jorgacevski J, Kreft M, Zorec R, Rosa JM, Gandia L, Gutiérrez LM, Binz T, Giniatullin R, Kavalali ET, Davletov B. Darios F, et al. Among authors: davletov b. Neuron. 2009 Jun 11;62(5):683-94. doi: 10.1016/j.neuron.2009.04.024. Neuron. 2009. PMID: 19524527 Free PMC article.
SNARE tagging allows stepwise assembly of a multimodular medicinal toxin.
Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B. Darios F, et al. Among authors: davletov b. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18197-201. doi: 10.1073/pnas.1007125107. Epub 2010 Oct 4. Proc Natl Acad Sci U S A. 2010. PMID: 20921391 Free PMC article.
Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity.
Ferrari E, Maywood ES, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings MH, Niranjan D, Schiavo G, Davletov B. Ferrari E, et al. Among authors: davletov b. Toxins (Basel). 2011 Apr;3(4):345-55. doi: 10.3390/toxins3040345. Epub 2011 Mar 24. Toxins (Basel). 2011. PMID: 22069712 Free PMC article.
98 results