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Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion.
Tengesdal IW, Menon DR, Osborne DG, Neff CP, Powers NE, Gamboni F, Mauro AG, D'Alessandro A, Stefanoni D, Henen MA, Mills TS, De Graaf DM, Azam T, Vogeli B, Palmer BE, Pietras EM, DeGregori J, Tan AC, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. Tengesdal IW, et al. Among authors: de graaf dm. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2000915118. doi: 10.1073/pnas.2000915118. Proc Natl Acad Sci U S A. 2021. PMID: 33649199 Free PMC article.
Biology of IL-38 and its role in disease.
van de Veerdonk FL, de Graaf DM, Joosten LA, Dinarello CA. van de Veerdonk FL, et al. Among authors: de graaf dm. Immunol Rev. 2018 Jan;281(1):191-196. doi: 10.1111/imr.12612. Immunol Rev. 2018. PMID: 29247986 Review.
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease.
Højen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckman K, Fujita M, Fischer S, Dinarello CA. Højen JF, et al. Among authors: de graaf dm. Nat Immunol. 2019 Sep;20(9):1138-1149. doi: 10.1038/s41590-019-0467-1. Epub 2019 Aug 19. Nat Immunol. 2019. PMID: 31427775 Free PMC article.
PASylation of IL-1 receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis.
Powers NE, Swartzwelter B, Marchetti C, de Graaf DM, Lerchner A, Schlapschy M, Datar R, Binder U, Edwards CK 3rd, Skerra A, Dinarello CA. Powers NE, et al. Among authors: de graaf dm. J Biol Chem. 2020 Jan 17;295(3):868-882. doi: 10.1074/jbc.RA119.010340. Epub 2019 Dec 9. J Biol Chem. 2020. PMID: 31819009 Free PMC article.
Reduced concentrations of the B cell cytokine interleukin 38 are associated with cardiovascular disease risk in overweight subjects.
de Graaf DM, Jaeger M, van den Munckhof ICL, Ter Horst R, Schraa K, Zwaag J, Kox M, Fujita M, Yamauchi T, Mercurio L, Madonna S, Rutten JHW, de Graaf J, Riksen NP, van de Veerdonk FL, Netea MG, Joosten LAB, Dinarello CA. de Graaf DM, et al. Among authors: de graaf j. Eur J Immunol. 2021 Mar;51(3):662-671. doi: 10.1002/eji.201948390. Epub 2020 Nov 19. Eur J Immunol. 2021. PMID: 33125159 Free PMC article.
A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling.
Li S, Jiang L, Beckmann K, Højen JF, Pessara U, Powers NE, de Graaf DM, Azam T, Lindenberger J, Eisenmesser EZ, Fischer S, Dinarello CA. Li S, et al. Among authors: de graaf dm. J Biol Chem. 2021 Jan-Jun;296:100630. doi: 10.1016/j.jbc.2021.100630. Epub 2021 Apr 3. J Biol Chem. 2021. PMID: 33823154 Free PMC article.
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