De Strooper B - Search Results

1

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins.

Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. Tomita T, et al. Among authors: de strooper b. J Biol Chem. 2001 Aug 31;276(35):33273-81. doi: 10.1074/jbc.M011152200. Epub 2001 Jun 29. J Biol Chem. 2001. PMID: 11432849 Free article.

2

Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.

De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. De Strooper B, et al. J Biol Chem. 1995 Feb 24;270(8):4058-65. doi: 10.1074/jbc.270.8.4058. J Biol Chem. 1995. PMID: 7876155 Free article.

3

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. De Strooper B, et al. J Biol Chem. 1997 Feb 7;272(6):3590-8. doi: 10.1074/jbc.272.6.3590. J Biol Chem. 1997. PMID: 9013610 Free article.

4

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645

5

Processing of beta-secretase by furin and other members of the proprotein convertase family.

Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B. Creemers JW, et al. Among authors: de strooper b. J Biol Chem. 2001 Feb 9;276(6):4211-7. doi: 10.1074/jbc.M006947200. Epub 2000 Nov 8. J Biol Chem. 2001. PMID: 11071887 Free article.

6

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P. Wiltfang J, et al. Among authors: de strooper b. J Biol Chem. 2001 Nov 16;276(46):42645-57. doi: 10.1074/jbc.M102790200. Epub 2001 Aug 28. J Biol Chem. 2001. PMID: 11526104 Free article.

7

Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein.

Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H. Sai X, et al. Among authors: de strooper b. J Biol Chem. 2002 Apr 12;277(15):12915-20. doi: 10.1074/jbc.M112372200. Epub 2002 Jan 17. J Biol Chem. 2002. PMID: 11799129 Free article.

8

Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44.

Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Murakami D, et al. Among authors: de strooper b. Oncogene. 2003 Mar 13;22(10):1511-6. doi: 10.1038/sj.onc.1206298. Oncogene. 2003. PMID: 12629514

9

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.

Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B. Nyabi O, et al. Among authors: de strooper b. J Biol Chem. 2003 Oct 31;278(44):43430-6. doi: 10.1074/jbc.M306957200. Epub 2003 Jul 28. J Biol Chem. 2003. PMID: 12885769 Free article.

10

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.

Schulz JG, Annaert W, Vandekerckhove J, Zimmermann P, De Strooper B, David G. Schulz JG, et al. Among authors: de strooper b. J Biol Chem. 2003 Dec 5;278(49):48651-7. doi: 10.1074/jbc.M308424200. Epub 2003 Sep 22. J Biol Chem. 2003. PMID: 14504279 Free article.

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