De Strooper B - Search Results

1

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

Wakabayashi T, De Strooper B. Wakabayashi T, et al. Among authors: de strooper b. Physiology (Bethesda). 2008 Aug;23:194-204. doi: 10.1152/physiol.00009.2008. Physiology (Bethesda). 2008. PMID: 18697993 Free article. Review.

2

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. De Strooper B, et al. Nature. 1999 Apr 8;398(6727):518-22. doi: 10.1038/19083. Nature. 1999. PMID: 10206645

3

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B. De Jonghe C, et al. Among authors: de strooper b. Hum Mol Genet. 2001 Aug 1;10(16):1665-71. doi: 10.1093/hmg/10.16.1665. Hum Mol Genet. 2001. PMID: 11487570

4

Gamma-secretase: never more enigmatic.

Sisodia SS, Annaert W, Kim SH, De Strooper B. Sisodia SS, et al. Among authors: de strooper b. Trends Neurosci. 2001 Nov;24(11 Suppl):S2-6. doi: 10.1016/s0166-2236(00)01987-1. Trends Neurosci. 2001. PMID: 11881741 Review.

5

A cell biological perspective on Alzheimer's disease.

Annaert W, De Strooper B. Annaert W, et al. Among authors: de strooper b. Annu Rev Cell Dev Biol. 2002;18:25-51. doi: 10.1146/annurev.cellbio.18.020402.142302. Epub 2002 Apr 2. Annu Rev Cell Dev Biol. 2002. PMID: 12142279 Review.

6

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P. Hartmann D, et al. Among authors: de strooper b. Hum Mol Genet. 2002 Oct 1;11(21):2615-24. doi: 10.1093/hmg/11.21.2615. Hum Mol Genet. 2002. PMID: 12354787

7

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.

Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B. Herreman A, et al. Among authors: de strooper b. J Cell Sci. 2003 Mar 15;116(Pt 6):1127-36. doi: 10.1242/jcs.00292. J Cell Sci. 2003. PMID: 12584255 Free article.

8

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.

De Strooper B. De Strooper B. Neuron. 2003 Apr 10;38(1):9-12. doi: 10.1016/s0896-6273(03)00205-8. Neuron. 2003. PMID: 12691659 Free article. Review.

9

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.

Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B. Nyabi O, et al. Among authors: de strooper b. J Biol Chem. 2003 Oct 31;278(44):43430-6. doi: 10.1074/jbc.M306957200. Epub 2003 Jul 28. J Biol Chem. 2003. PMID: 12885769 Free article.

10

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling.

Schulz JG, Annaert W, Vandekerckhove J, Zimmermann P, De Strooper B, David G. Schulz JG, et al. Among authors: de strooper b. J Biol Chem. 2003 Dec 5;278(49):48651-7. doi: 10.1074/jbc.M308424200. Epub 2003 Sep 22. J Biol Chem. 2003. PMID: 14504279 Free article.

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