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The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.
Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P. Sesti G, et al. Among authors: del guerra s. J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. doi: 10.1210/jc.2005-2323. Epub 2006 Apr 4. J Clin Endocrinol Metab. 2006. PMID: 16595597
Characterization of sulfonylurea receptors in isolated human pancreatic islets.
Giannaccini G, Lupi R, Trincavelli ML, Navalesi R, Betti L, Marchetti P, Lucacchini A, Del Guerra S, Martini C. Giannaccini G, et al. Among authors: del guerra s. J Cell Biochem. 1998 Nov 1;71(2):182-8. doi: 10.1002/(sici)1097-4644(19981101)71:2<182::aid-jcb4>3.0.co;2-r. J Cell Biochem. 1998. PMID: 9779817
Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines.
Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, Realacci M, del Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R, Marchetti P. Marselli L, et al. Among authors: del guerra s. J Clin Endocrinol Metab. 2001 Oct;86(10):4974-8. doi: 10.1210/jcem.86.10.7938. J Clin Endocrinol Metab. 2001. PMID: 11600573
Lipotoxicity in human pancreatic islets and the protective effect of metformin.
Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patanè G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P. Lupi R, et al. Among authors: del guerra s, del prato s. Diabetes. 2002 Feb;51 Suppl 1:S134-7. doi: 10.2337/diabetes.51.2007.s134. Diabetes. 2002. PMID: 11815472
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P. Lupi R, et al. Among authors: del guerra s, del prato s. Diabetes. 2002 May;51(5):1437-42. doi: 10.2337/diabetes.51.5.1437. Diabetes. 2002. PMID: 11978640
74 results