Demarest KT - Search Results

1

Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.

Zhang X, Urbanski M, Patel M, Cox GG, Zeck RE, Bian H, Conway BR, Beavers MP, Rybczynski PJ, Demarest KT. Zhang X, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1696-701. doi: 10.1016/j.bmcl.2005.12.006. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16380256

2

Benzoxazinones as PPARgamma agonists. part 1: SAR of three aromatic regions.

Rybczynski PJ, Zeck RE, Combs DW, Turchi I, Burris TP, Xu JZ, Yang M, Demarest KT. Rybczynski PJ, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2359-62. doi: 10.1016/s0960-894x(03)00401-3. Bioorg Med Chem Lett. 2003. PMID: 12824034

3

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

Zhang HC, White KB, Ye H, McComsey DF, Derian CK, Addo MF, Andrade-Gordon P, Eckardt AJ, Conway BR, Westover L, Xu JZ, Look R, Demarest KT, Emanuel S, Maryanoff BE. Zhang HC, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53. doi: 10.1016/s0960-894x(03)00644-9. Bioorg Med Chem Lett. 2003. PMID: 12941331

4

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.

Kuo GH, Prouty C, DeAngelis A, Shen L, O'Neill DJ, Shah C, Connolly PJ, Murray WV, Conway BR, Cheung P, Westover L, Xu JZ, Look RA, Demarest KT, Emanuel S, Middleton SA, Jolliffe L, Beavers MP, Chen X. Kuo GH, et al. Among authors: demarest kt. J Med Chem. 2003 Sep 11;46(19):4021-31. doi: 10.1021/jm030115o. J Med Chem. 2003. PMID: 12954055

5

2,5-disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists.

Urbanski MJ, Chen RH, Demarest KT, Gunnet J, Look R, Ericson E, Murray WV, Rybczynski PJ, Zhang X. Urbanski MJ, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4031-4. doi: 10.1016/j.bmcl.2003.08.051. Bioorg Med Chem Lett. 2003. PMID: 14592501

6

Benzoxazinones as PPARgamma agonists. 2. SAR of the amide substituent and in vivo results in a type 2 diabetes model.

Rybczynski PJ, Zeck RE, Dudash J Jr, Combs DW, Burris TP, Yang M, Osborne MC, Chen X, Demarest KT. Rybczynski PJ, et al. Among authors: demarest kt. J Med Chem. 2004 Jan 1;47(1):196-209. doi: 10.1021/jm0301888. J Med Chem. 2004. PMID: 14695833

7

Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors.

Shen L, Prouty C, Conway BR, Westover L, Xu JZ, Look RA, Chen X, Beavers MP, Roberts J, Murray WV, Demarest KT, Kuo GH. Shen L, et al. Among authors: demarest kt. Bioorg Med Chem. 2004 Mar 1;12(5):1239-55. doi: 10.1016/j.bmc.2003.09.047. Bioorg Med Chem. 2004. PMID: 14980636

8

Synthesis and evaluation of nonpeptide substituted spirobenzazepines as potent vasopressin antagonists.

Xiang MA, Chen RH, Demarest KT, Gunnet J, Look R, Hageman W, Murray WV, Combs DW, Rybczynski PJ, Patel M. Xiang MA, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3143-6. doi: 10.1016/j.bmcl.2004.04.016. Bioorg Med Chem Lett. 2004. PMID: 15149662

9

Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3beta (GSK-3beta) inhibitors.

O'Neill DJ, Shen L, Prouty C, Conway BR, Westover L, Xu JZ, Zhang HC, Maryanoff BE, Murray WV, Demarest KT, Kuo GH. O'Neill DJ, et al. Among authors: demarest kt. Bioorg Med Chem. 2004 Jun 15;12(12):3167-85. doi: 10.1016/j.bmc.2004.04.010. Bioorg Med Chem. 2004. PMID: 15158785

10

Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitors.

Dudash J Jr, Zhang X, Zeck RE, Johnson SG, Cox GG, Conway BR, Rybczynski PJ, Demarest KT. Dudash J Jr, et al. Among authors: demarest kt. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5121-5. doi: 10.1016/j.bmcl.2004.07.082. Bioorg Med Chem Lett. 2004. PMID: 15380212

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