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A defined synthetic substrate for serum-free culture of human stem cell derived cardiomyocytes with improved functional maturity identified using combinatorial materials microarrays.
Patel AK, Celiz AD, Rajamohan D, Anderson DG, Langer R, Davies MC, Alexander MR, Denning C. Patel AK, et al. Among authors: denning c. Biomaterials. 2015 Aug;61:257-65. doi: 10.1016/j.biomaterials.2015.05.019. Epub 2015 May 15. Biomaterials. 2015. PMID: 26005764 Free PMC article.
Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.
Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE. Denning C, et al. Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1728-48. doi: 10.1016/j.bbamcr.2015.10.014. Epub 2015 Oct 31. Biochim Biophys Acta. 2016. PMID: 26524115 Free PMC article.
CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy.
Mosqueira D, Mannhardt I, Bhagwan JR, Lis-Slimak K, Katili P, Scott E, Hassan M, Prondzynski M, Harmer SC, Tinker A, Smith JGW, Carrier L, Williams PM, Gaffney D, Eschenhagen T, Hansen A, Denning C. Mosqueira D, et al. Among authors: denning c. Eur Heart J. 2018 Nov 14;39(43):3879-3892. doi: 10.1093/eurheartj/ehy249. Eur Heart J. 2018. PMID: 29741611 Free PMC article.
206 results