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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 2
1965 1
1966 3
1967 1
1969 2
1971 2
1973 2
1975 2
1976 4
1977 2
1978 5
1979 8
1980 7
1981 5
1982 3
1983 12
1984 14
1985 13
1986 12
1987 14
1988 9
1989 6
1990 8
1991 16
1992 10
1993 9
1994 20
1995 9
1996 17
1997 7
1998 11
1999 14
2000 19
2001 15
2002 14
2003 11
2004 9
2005 18
2006 17
2007 11
2008 19
2009 15
2010 16
2011 13
2012 11
2013 15
2014 15
2015 11
2016 14
2017 16
2018 9
2019 10
2020 10
2021 15
2022 14
2023 22
2024 8

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569 results

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Page 1
Breakage of cytoplasmic chromosomes by pathological DNA base excision repair.
Tang S, Stokasimov E, Cui Y, Pellman D. Tang S, et al. Nature. 2022 Jun;606(7916):930-936. doi: 10.1038/s41586-022-04767-1. Epub 2022 Apr 27. Nature. 2022. PMID: 35477155 Free PMC article.
Micronuclei accumulate large amounts of RNA-DNA hybrids, which are edited by adenine deaminases acting on RNA (ADAR enzymes) to generate deoxyinosine. Deoxyinosine is then converted into abasic sites by a DNA base excision repair (BER) glycosylase, N-methyl-purine D …
Micronuclei accumulate large amounts of RNA-DNA hybrids, which are edited by adenine deaminases acting on RNA (ADAR enzymes) to generate …
Adenosine deaminase: functional implications and different classes of inhibitors.
Cristalli G, Costanzi S, Lambertucci C, Lupidi G, Vittori S, Volpini R, Camaioni E. Cristalli G, et al. Med Res Rev. 2001 Mar;21(2):105-28. doi: 10.1002/1098-1128(200103)21:2<105::aid-med1002>3.0.co;2-u. Med Res Rev. 2001. PMID: 11223861 Review.
Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine, respectively. This ubiquitous enzyme has been found in a wide variety of microorganisms, plants, and in …
Adenosine deaminase (ADA) is an enzyme of the purine metabolism which catalyzes the irreversible deamination of adenosine and deoxyadenosine …
A shattering experience.
Haber JE. Haber JE. Mol Cell. 2022 Jul 7;82(13):2360-2362. doi: 10.1016/j.molcel.2022.06.018. Mol Cell. 2022. PMID: 35803217 Free article.
Tang et al. (2022) report that the DNA breaks that provoke chromothripsis-the pulverization and dramatic assembly into a rearranged chromosome-are generated by the base excision repair APE1 endonuclease, triggered by removing deoxyinosines that are created in DNA::RNA hybr …
Tang et al. (2022) report that the DNA breaks that provoke chromothripsis-the pulverization and dramatic assembly into a rearranged chromoso …
Bioactivity of 2'-deoxyinosine-incorporated aptamer AS1411.
Fan X, Sun L, Wu Y, Zhang L, Yang Z. Fan X, et al. Sci Rep. 2016 May 19;6:25799. doi: 10.1038/srep25799. Sci Rep. 2016. PMID: 27194215 Free PMC article.
Aptamers can be chemically modified to enhance nuclease resistance and increase target affinity. In this study, we performed chemical modification of 2'-deoxyinosine in AS1411, an anti-proliferative G-rich oligodeoxynucleotide aptamer, which binds selectively to the nucleo …
Aptamers can be chemically modified to enhance nuclease resistance and increase target affinity. In this study, we performed chemical modifi …
Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases.
Kutryb-Zajac B, Mierzejewska P, Slominska EM, Smolenski RT. Kutryb-Zajac B, et al. Molecules. 2020 Oct 12;25(20):4652. doi: 10.3390/molecules25204652. Molecules. 2020. PMID: 33053898 Free PMC article. Review.
Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2'deoxyadenosine to 2'deoxyinosine. ADA is active both inside the cell and on the cell surface where it was found to interact with membrane proteins, such as CD26 …
Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts adenosine to inosine or 2'deoxyadenosine to 2'deox …
An adenine base editor variant expands context compatibility.
Xiao YL, Wu Y, Tang W. Xiao YL, et al. Nat Biotechnol. 2024 Jan 2. doi: 10.1038/s41587-023-01994-3. Online ahead of print. Nat Biotechnol. 2024. PMID: 38168987
Adenine base editors (ABEs) are precise gene-editing agents that convert A:T pairs into G:C through a deoxyinosine intermediate. Existing ABEs function most effectively when the target A is in a TA context. ...
Adenine base editors (ABEs) are precise gene-editing agents that convert A:T pairs into G:C through a deoxyinosine intermediate. Exis …
Diversity of Endonuclease V: From DNA Repair to RNA Editing.
Kuraoka I. Kuraoka I. Biomolecules. 2015 Sep 24;5(4):2194-206. doi: 10.3390/biom5042194. Biomolecules. 2015. PMID: 26404388 Free PMC article. Review.
In such cases, removal of deaminated products from DNA and RNA by a nuclease might be required depending on the cellular function. One such enzyme, endonuclease V, recognizes deoxyinosine and cleaves 3' end of the damaged base in double-stranded DNA through an alternative …
In such cases, removal of deaminated products from DNA and RNA by a nuclease might be required depending on the cellular function. One such …
Human Mitochondrial Protein HSPD1 Binds to and Regulates the Repair of Deoxyinosine in DNA.
Zheng X, Chang S, Liu Y, Dai X, You C. Zheng X, et al. J Proteome Res. 2023 Apr 7;22(4):1339-1346. doi: 10.1021/acs.jproteome.2c00854. Epub 2023 Feb 28. J Proteome Res. 2023. PMID: 36852893
The generation of deoxyinosine (dI) in DNA is one of the most important sources of genetic mutations, which may lead to cancer and other human diseases. ...
The generation of deoxyinosine (dI) in DNA is one of the most important sources of genetic mutations, which may lead to cancer and ot …
Endonuclease V: an unusual enzyme for repair of DNA deamination.
Cao W. Cao W. Cell Mol Life Sci. 2013 Sep;70(17):3145-56. doi: 10.1007/s00018-012-1222-z. Epub 2012 Dec 20. Cell Mol Life Sci. 2013. PMID: 23263163 Free PMC article. Review.
Endonuclease V (endo V) was first discovered as the fifth endonuclease in Escherichia coli in 1977 and later rediscovered as a deoxyinosine 3' endonuclease. Decades of biochemical and genetic investigations have accumulated rich information on its role as a DNA repair enzy …
Endonuclease V (endo V) was first discovered as the fifth endonuclease in Escherichia coli in 1977 and later rediscovered as a deoxyinosi …
569 results