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Year Number of Results
2004 6
2005 10
2006 11
2007 9
2008 4
2009 3
2010 7
2011 4
2012 3
2013 2
2014 1
2015 2
2016 2
2017 2
2020 1
2021 3
2022 1
2023 2
2024 0

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68 results

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Page 1
Evaluation of bioadhesive gels for local action in the esophagus.
Shanthi Chede L, Donovan MD. Shanthi Chede L, et al. Int J Pharm. 2023 Jul 25;642:123115. doi: 10.1016/j.ijpharm.2023.123115. Epub 2023 Jun 9. Int J Pharm. 2023. PMID: 37302670
Exposure of a segment of esophagus to the ciclesonide-containing gels resulted in therapeutic concentrations of des-ciclesonide, the active drug metabolite, in the tissues within 30 min. Increasing des-CIC concentrations were also observed over a 3-hour exposure int …
Exposure of a segment of esophagus to the ciclesonide-containing gels resulted in therapeutic concentrations of des-ciclesonide, the active …
LC-HRMS/MS study of the prodrug ciclesonide and its active metabolite desisobutyryl-ciclesonide in plasma after an inhalative administration to horses for doping control purposes.
Trevisiol S, Moulard Y, Kaabia Z, Delcourt V, Loup B, Garcia P, Boyer S, Dauriac K, Groseille G, Rouger S, Narbe R, Popot MA, Bailly-Chouriberry L. Trevisiol S, et al. Drug Test Anal. 2022 Feb;14(2):252-261. doi: 10.1002/dta.3174. Epub 2021 Oct 30. Drug Test Anal. 2022. PMID: 34634175
This prodrug is rapidly converted to desisobutyryl-ciclesonide (des-CIC), the main pharmacologically active compound. Due to its anti-inflammatory properties, CIC is prohibited for use in horse competitions. ...Therefore, a highly sensitive analytical method based o …
This prodrug is rapidly converted to desisobutyryl-ciclesonide (des-CIC), the main pharmacologically active compound. Due to i …
Ciclesonide activates glucocorticoid signaling in neonatal rat lung but does not trigger adverse effects in the cortex and cerebellum.
Jaumotte JD, Franks AL, Bargerstock EM, Kisanga EP, Menden HL, Ghersi A, Omar M, Wang L, Rudine A, Short KL, Silswal N, Cole TJ, Sampath V, Monaghan-Nichols AP, DeFranco DB. Jaumotte JD, et al. Neurobiol Dis. 2021 Aug;156:105422. doi: 10.1016/j.nbd.2021.105422. Epub 2021 Jun 11. Neurobiol Dis. 2021. PMID: 34126164 Free PMC article.
Carboxylesterases enriched in the lower airways convert CIC to the glucocorticoid receptor (GR) agonist des-CIC. We therefore examined whether CIC would likewise activate GR in neonatal lung but have limited adverse extra-pulmonary effects, particularly in the devel …
Carboxylesterases enriched in the lower airways convert CIC to the glucocorticoid receptor (GR) agonist des-CIC. We therefore …
Visualizing the spatial localization of ciclesonide and its metabolites in rat lungs after inhalation of 1-μm aerosol of ciclesonide by desorption electrospray ionization-time of flight mass spectrometry imaging.
Yamamoto E, Taquahashi Y, Kuwagata M, Saito H, Matsushita K, Toyoda T, Sato F, Kitajima S, Ogawa K, Izutsu KI, Saito Y, Hirabayashi Y, Iimura Y, Honma M, Okuda H, Goda Y. Yamamoto E, et al. Int J Pharm. 2021 Feb 15;595:120241. doi: 10.1016/j.ijpharm.2021.120241. Epub 2021 Jan 21. Int J Pharm. 2021. PMID: 33484917 Free article.
We visualized two-dimensional spatial localization of CIC and its metabolites in rat lungs after administration of a single dose of a CIC aerosol (with the mass median aerodynamic diameter of 0.918-1.168 mum) using desorption electrospray ionization-time of flight mass spectromet …
We visualized two-dimensional spatial localization of CIC and its metabolites in rat lungs after administration of a single dose of a CIC ae …
An Ultrasensitive LC-APPI-MS/MS Method for Simultaneous Determination of Ciclesonide and Active Metabolite Desisobutyryl-Ciclesonide in Human Serum and Its Application to a Clinical Study.
Chen YL, Wang W, Gatien Ngounou Wetie A, Shi L, Eddy J, John Lin ZP, Sunkaraneni S. Chen YL, et al. J Appl Lab Med. 2020 Jan 1;5(1):41-53. doi: 10.1373/jalm.2019.029397. J Appl Lab Med. 2020. PMID: 31662413 Free article.
CONCLUSION: APPI, a highly selective and sensitive ionization source, made possible for quantifying CIC and des-CIC with a lower limit of quantification (LLOQ) of 1 pg/mL in human serum by LC-MS/MS. A 10-fold sensitivity improvement from the most sensitive reported …
CONCLUSION: APPI, a highly selective and sensitive ionization source, made possible for quantifying CIC and des-CIC with a low …
Efficacy and safety of inhaled corticosteroids relative to fluticasone propionate: a systematic review of randomized controlled trials in asthma.
Yeo SH, Aggarwal B, Shantakumar S, Mulgirigama A, Daley-Yates P. Yeo SH, et al. Expert Rev Respir Med. 2017 Oct;11(10):763-778. doi: 10.1080/17476348.2017.1361824. Epub 2017 Aug 4. Expert Rev Respir Med. 2017. PMID: 28752776 Review.
However, CIC appeared to have a smaller impact on cortisol levels than FP, which is likely due to CIC's incomplete conversion to active metabolite (des-CIC) and the lower potency of des-CIC compared with FP. Although there were no significant differenc …
However, CIC appeared to have a smaller impact on cortisol levels than FP, which is likely due to CIC's incomplete conversion to active meta …
[Good professional practices of French CICs - version # 2].
Chevassus H, Duchesne C, Sailly A, Vigouroux C, Foulon C, Kubiak C, Binquet C, Felin AL, Chaud P, Thalamas C, Cornu C; QUALI-CIC. Chevassus H, et al. Therapie. 2017 Oct;72(5):525-538. doi: 10.1016/j.therap.2017.01.006. Epub 2017 Feb 17. Therapie. 2017. PMID: 28389014 French.
[ECRIN standard requirements for good clinical practices-compliant data management in multinational clinical trials].
Cornu C, Donche A, Coffre C, Le Gouge A, Rym B, Vaugier I, Barbot F, Leizorovicz A, Juge N, Giraud C, Gueyffier F, Félin A, Mura T, Chevassus H, Binquet C; Comité de pilotage du groupe de travail harmonisation des procédures de réseau des CIC. Cornu C, et al. Therapie. 2023 Sep-Oct;78(5S):S11-S18. doi: 10.2515/therapie/2015042. Epub 2016 Oct 13. Therapie. 2023. PMID: 27839710 French.
68 results