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Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies.
Desta Z, Soukhova N, Mahal SK, Flockhart DA. Desta Z, et al. Drug Metab Dispos. 2000 Jul;28(7):789-800. Drug Metab Dispos. 2000. PMID: 10859153
Using human liver microsomes (HLMs) and recombinant cytochrome P450s (CYP450s), we characterized the CYP450 isoforms involved in the primary metabolic pathways of cisapride and documented the ability of cisapride to inhibit the CYP450 …
Using human liver microsomes (HLMs) and recombinant cytochrome P450s (CYP450s), we characterized the CYP450 isoforms involved …
Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A.
Desta Z, Soukhova N, Morocho AM, Flockhart DA. Desta Z, et al. J Pharmacol Exp Ther. 2001 Aug;298(2):508-20. J Pharmacol Exp Ther. 2001. PMID: 11454912
Studies with (-)-, (+)-, and (+/-)-cisapride were undertaken in human liver microsomes (HLMs) and recombinant cytochrome P450s (P450s) to determine the stereoselective metabolism and enantiomer-enantiomer interaction. ...When incubated si …
Studies with (-)-, (+)-, and (+/-)-cisapride were undertaken in human liver microsomes (HLMs) and recombinant cytoch …