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774 results

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Page 1
The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise?
Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, Di L, Platt BJ, Neal S, Dwyer JM, Bender CN, Zhang J, Lock T, Kowal D, Kramer A, Randall A, Huselton C, Vishwanathan K, Tse SY, Butera J, Ring RH, Rosenzweig-Lipson S, Hughes ZA, Dunlop J. Sukoff Rizzo SJ, et al. Among authors: di l. J Pharmacol Exp Ther. 2011 Jul;338(1):345-52. doi: 10.1124/jpet.110.177378. Epub 2011 Apr 20. J Pharmacol Exp Ther. 2011. PMID: 21508084
Identification of a series of benzoxazoles as potent 5-HT6 ligands.
Liu KG, Lo JR, Comery TA, Zhang GM, Zhang JY, Kowal DM, Smith DL, Di L, Kerns EH, Schechter LE, Robichaud AJ. Liu KG, et al. Among authors: di l. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1115-7. doi: 10.1016/j.bmcl.2008.12.107. Epub 2009 Jan 3. Bioorg Med Chem Lett. 2009. PMID: 19152787
1-Sulfonylindazoles as potent and selective 5-HT6 ligands.
Liu KG, Lo JR, Comery TA, Zhang GM, Zhang JY, Kowal DM, Smith DL, Di L, Kerns EH, Schechter LE, Robichaud AJ. Liu KG, et al. Among authors: di l. Bioorg Med Chem Lett. 2009 May 1;19(9):2413-5. doi: 10.1016/j.bmcl.2009.03.071. Epub 2009 Mar 21. Bioorg Med Chem Lett. 2009. PMID: 19345582
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).
Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U. Ghiron C, et al. Among authors: di l. J Med Chem. 2010 Jun 10;53(11):4379-89. doi: 10.1021/jm901692q. J Med Chem. 2010. PMID: 20465311
Pyrrolidin-3-yl-N-methylbenzamides as potent histamine 3 receptor antagonists.
Zhou D, Gross JL, Sze JY, Adedoyin AB, Bowlby M, Di L, Platt BJ, Zhang G, Brandon N, Comery TA, Robichaud AJ. Zhou D, et al. Among authors: di l. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5957-60. doi: 10.1016/j.bmcl.2011.07.061. Epub 2011 Jul 27. Bioorg Med Chem Lett. 2011. PMID: 21843941
Discovery of (2S,4R)-1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid hydrochloride (GAP-134)13, an orally active small molecule gap-junction modifier for the treatment of atrial fibrillation.
Butera JA, Larsen BD, Hennan JK, Kerns E, Di L, Alimardanov A, Swillo RE, Morgan GA, Liu K, Wang Q, Rossman EI, Unwalla R, McDonald L, Huselton C, Petersen JS. Butera JA, et al. Among authors: di l. J Med Chem. 2009 Feb 26;52(4):908-11. doi: 10.1021/jm801558d. J Med Chem. 2009. PMID: 19175320
774 results