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uPAR isoform 2 forms a dimer and induces severe kidney disease in mice.
Wei C, Li J, Adair BD, Zhu K, Cai J, Merchant M, Samelko B, Liao Z, Koh KH, Tardi NJ, Dande RR, Liu S, Ma J, Dibartolo S, Hägele S, Peev V, Hayek SS, Cimbaluk DJ, Tracy M, Klein J, Sever S, Shattil SJ, Arnaout MA, Reiser J. Wei C, et al. Among authors: dibartolo s. J Clin Invest. 2019 Apr 2;129(5):1946-1959. doi: 10.1172/JCI124793. eCollection 2019 Apr 2. J Clin Invest. 2019. PMID: 30730305 Free PMC article.
Genetic variation in APOL1 associates with younger age at hemodialysis initiation.
Kanji Z, Powe CE, Wenger JB, Huang C, Ankers E, Sullivan DA, Collerone G, Powe NR, Tonelli M, Bhan I, Bernhardy AJ, Dibartolo S, Friedman D, Genovese G, Pollak MR, Thadhani R. Kanji Z, et al. Among authors: dibartolo s. J Am Soc Nephrol. 2011 Nov;22(11):2091-7. doi: 10.1681/ASN.2010121234. Epub 2011 Oct 13. J Am Soc Nephrol. 2011. PMID: 21997398 Free PMC article.
APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.
Olabisi OA, Zhang JY, VerPlank L, Zahler N, DiBartolo S 3rd, Heneghan JF, Schlöndorff JS, Suh JH, Yan P, Alper SL, Friedman DJ, Pollak MR. Olabisi OA, et al. Among authors: dibartolo s 3rd. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):830-7. doi: 10.1073/pnas.1522913113. Epub 2015 Dec 23. Proc Natl Acad Sci U S A. 2016. PMID: 26699492 Free PMC article.