Dickey CA - Search Results

1

Brain CHIP: removing the culprits in neurodegenerative disease.

Dickey CA, Patterson C, Dickson D, Petrucelli L. Dickey CA, et al. Trends Mol Med. 2007 Jan;13(1):32-8. doi: 10.1016/j.molmed.2006.11.003. Epub 2006 Nov 28. Trends Mol Med. 2007. PMID: 17127096 Review.

2

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors.

Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Dickey CA, et al. Curr Alzheimer Res. 2005 Apr;2(2):231-8. doi: 10.2174/1567205053585927. Curr Alzheimer Res. 2005. PMID: 15974923

3

Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy.

Lee WC, Courtenay A, Troendle FJ, Stallings-Mann ML, Dickey CA, DeLucia MW, Dickson DW, Eckman CB. Lee WC, et al. Among authors: dickey ca. FASEB J. 2005 Sep;19(11):1549-51. doi: 10.1096/fj.05-3826fje. Epub 2005 Jun 29. FASEB J. 2005. PMID: 15987783

4

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.

Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. Dickey CA, et al. FASEB J. 2006 Apr;20(6):753-5. doi: 10.1096/fj.05-5343fje. Epub 2006 Feb 7. FASEB J. 2006. PMID: 16464956

5

Suppression of galactosylceramidase (GALC) expression in the twitcher mouse model of globoid cell leukodystrophy (GLD) is caused by nonsense-mediated mRNA decay (NMD).

Lee WC, Tsoi YK, Dickey CA, Delucia MW, Dickson DW, Eckman CB. Lee WC, et al. Among authors: dickey ca. Neurobiol Dis. 2006 Aug;23(2):273-80. doi: 10.1016/j.nbd.2006.03.005. Epub 2006 Jun 8. Neurobiol Dis. 2006. PMID: 16759875

6

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Dickey CA, et al. J Neurosci. 2006 Jun 28;26(26):6985-96. doi: 10.1523/JNEUROSCI.0746-06.2006. J Neurosci. 2006. PMID: 16807328 Free PMC article.

7

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.

Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M. Baker M, et al. Among authors: dickey ca. Nature. 2006 Aug 24;442(7105):916-9. doi: 10.1038/nature05016. Epub 2006 Jul 16. Nature. 2006. PMID: 16862116

8

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Dickey CA, et al. Mol Neurodegener. 2006 Jul 26;1:6. doi: 10.1186/1750-1326-1-6. Mol Neurodegener. 2006. PMID: 16930453 Free PMC article.

9

Current strategies for the treatment of Alzheimer's disease and other tauopathies.

Dickey CA, Petrucelli L. Dickey CA, et al. Expert Opin Ther Targets. 2006 Oct;10(5):665-76. doi: 10.1517/14728222.10.5.665. Expert Opin Ther Targets. 2006. PMID: 16981824 Review.

10

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS Jr, Hutton M, Burrows F, Petrucelli L. Dickey CA, et al. J Clin Invest. 2007 Mar;117(3):648-58. doi: 10.1172/JCI29715. Epub 2007 Feb 15. J Clin Invest. 2007. PMID: 17304350 Free PMC article.

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