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Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
Mol Cancer Ther. 2021 Dec;20(12):2317-2328. doi: 10.1158/1535-7163.MCT-21-0367. Epub 2021 Sep 28.
Mol Cancer Ther. 2021.
PMID: 34583982
Free PMC article.
The role of the alcohol and carboxylic acid in directed ruthenium-catalyzed C(sp3)-H α-alkylation of cyclic amines.
Bergman SD, Storr TE, Prokopcová H, Aelvoet K, Diels G, Meerpoel L, Maes BU.
Bergman SD, et al. Among authors: diels g.
Chemistry. 2012 Aug 13;18(33):10393-8. doi: 10.1002/chem.201201072. Epub 2012 Jul 11.
Chemistry. 2012.
PMID: 22786664
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Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.
Janssens F, Leenaerts J, Diels G, De Boeck B, Megens A, Langlois X, van Rossem K, Beetens J, Borgers M.
Janssens F, et al. Among authors: diels g.
J Med Chem. 2005 Mar 24;48(6):2154-66. doi: 10.1021/jm049495j.
J Med Chem. 2005.
PMID: 15771458
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Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.
Andrés JI, Alonso JM, Díaz A, Fernández J, Iturrino L, Martínez P, Matesanz E, Freyne EJ, Deroose F, Boeckx G, Petit D, Diels G, Megens A, Somers M, Van Wauwe J, Stoppie P, Cools M, De Clerck F, Peeters D, de Chaffoy D.
Andrés JI, et al. Among authors: diels g.
Bioorg Med Chem Lett. 2002 Feb 25;12(4):653-8. doi: 10.1016/s0960-894x(01)00817-4.
Bioorg Med Chem Lett. 2002.
PMID: 11844693
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Microwave assisted medicinal chemistry.
Alcázar J, Diels G, Schoentjes B.
Alcázar J, et al. Among authors: diels g.
Mini Rev Med Chem. 2007 Apr;7(4):345-69. doi: 10.2174/138955707780363846.
Mini Rev Med Chem. 2007.
PMID: 17430222
Review.
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Straightforward palladium-mediated synthesis and biological evaluation of benzo[j]phenanthridine-7,12-diones as anti-tuberculosis agents.
Cappoen D, Jacobs J, Nguyen Van T, Claessens S, Diels G, Anthonissen R, Einarsdottir T, Fauville M, Verschaeve L, Huygen K, De Kimpe N.
Cappoen D, et al. Among authors: diels g.
Eur J Med Chem. 2012 Feb;48:57-68. doi: 10.1016/j.ejmech.2011.11.033. Epub 2011 Dec 1.
Eur J Med Chem. 2012.
PMID: 22182928
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