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Mitigation of Insulin Resistance by Natural Products from a New Class of Molecules, Membrane-Active Immunomodulators.
Izbicka E, Streeper RT. Izbicka E, et al. Pharmaceuticals (Basel). 2023 Jun 21;16(7):913. doi: 10.3390/ph16070913. Pharmaceuticals (Basel). 2023. PMID: 37513825 Free PMC article. Review.
A representative MAIM, the naturally occurring medium chain fatty acid ester diethyl azelate (DEA), has been shown to increase the fluidity of cell plasma membranes with subsequent downstream effects on cellular signaling. ...
A representative MAIM, the naturally occurring medium chain fatty acid ester diethyl azelate (DEA), has been shown to increase …
Diethyl Azelate for the Treatment of Brown Recluse Spider Bite, a Neglected Orphan Indication.
Streeper RT, Izbicka E. Streeper RT, et al. In Vivo. 2022 Jan-Feb;36(1):86-93. doi: 10.21873/invivo.12679. In Vivo. 2022. PMID: 34972703 Free PMC article.
BACKGROUND/AIM: Brown recluse spider bite releases hemolytic and cytotoxic phospholipase D to the wound that may cause necrosis or even death. We examined diethyl azelate (DEA), a plasma membrane fluidizer with a broad range of immunomodulatory activities, as a pote …
BACKGROUND/AIM: Brown recluse spider bite releases hemolytic and cytotoxic phospholipase D to the wound that may cause necrosis or even deat …
Oral Azelaic Acid Ester Decreases Markers of Insulin Resistance in Overweight Human Male Subjects.
Streeper RT, Louden C, Izbicka E. Streeper RT, et al. In Vivo. 2020 May-Jun;34(3):1173-1186. doi: 10.21873/invivo.11890. In Vivo. 2020. PMID: 32354907 Free PMC article.
BACKGROUND/AIM: Insulin resistance (IR) is linked to increased risk of cardiovascular disease and cancer. We examined safety and efficacy of the natural product diethyl azelate (DEA) in overweight males with a varying degree of IR. ...
BACKGROUND/AIM: Insulin resistance (IR) is linked to increased risk of cardiovascular disease and cancer. We examined safety and efficacy of …
Membrane Active Immunomodulator As a Novel Therapy for an Infectious Bacterial Disease, Buruli Ulcer.
Izbicka E, Streeper RT, Louden C. Izbicka E, et al. In Vivo. 2022 Nov-Dec;36(6):2615-2629. doi: 10.21873/invivo.12996. In Vivo. 2022. PMID: 36309402 Free PMC article.
Given that currently there is no curative topical treatment for BU, our objective was to evaluate a plasma membrane fluidizer, diethyl azelate (DEA), as a potential novel topical therapy for BU. ...
Given that currently there is no curative topical treatment for BU, our objective was to evaluate a plasma membrane fluidizer, diethyl …
Adaptive Membrane Fluidity Modulation: A Feedback Regulated Homeostatic System and Target for Pharmacological Intervention.
Izbicka E, Streeper RT, Louden C. Izbicka E, et al. In Vivo. 2021 Nov-Dec;35(6):3073-3095. doi: 10.21873/invivo.12603. In Vivo. 2021. PMID: 34697139 Free PMC article.
We examined the therapeutic potential of the membrane fluidizer diethyl azelate (DEA) and related azelates. MATERIALS AND METHODS: The effects of azelates on plasma membrane fluidity and cell signaling were examined in primary human and murine cells and in vivo. ...
We examined the therapeutic potential of the membrane fluidizer diethyl azelate (DEA) and related azelates. MATERIALS AND METH …
A prodrug approach to enhance azelaic acid percutaneous availability.
Al-Marabeh S, Khalil E, Khanfar M, Al-Bakri AG, Alzweiri M. Al-Marabeh S, et al. Pharm Dev Technol. 2017 Jun;22(4):578-586. doi: 10.1080/10837450.2016.1200614. Epub 2016 Jun 27. Pharm Dev Technol. 2017. PMID: 27346659
The prodrug strategy to enhance azelaic acid diffusion through skin was not reported before. Thus, a lipophilic prodrug of azelaic acid (diethyl azelate [DEA]) was synthesized and investigated to improve percutaneous availability of azelaic acid, with a subsequent f …
The prodrug strategy to enhance azelaic acid diffusion through skin was not reported before. Thus, a lipophilic prodrug of azelaic acid ( …
Response of microbial community assembly and succession pattern to abiotic factors during the second round of light-flavor Baijiu fermentation.
Kang J, Hu Y, Jia L, Zhang M, Zhang Z, Huang X, Chen X, Han BZ. Kang J, et al. Food Res Int. 2022 Dec;162(Pt A):111915. doi: 10.1016/j.foodres.2022.111915. Epub 2022 Sep 13. Food Res Int. 2022. PMID: 36461181
A total of 54 volatile compounds were identified during the fermentation, among which 15 compounds, mainly including ethyl acetate, diethyl azelate, ethyl 2-hydroxyisocaproate, 3-furaldehyde, and ethylidene diacetate, were identified as important flavor metabolites. …
A total of 54 volatile compounds were identified during the fermentation, among which 15 compounds, mainly including ethyl acetate, dieth …
Characterization of key odorants in Chinese chixiang aroma-type liquor by gas chromatography-olfactometry, quantitative measurements, aroma recombination, and omission studies.
Fan H, Fan W, Xu Y. Fan H, et al. J Agric Food Chem. 2015 Apr 15;63(14):3660-8. doi: 10.1021/jf506238f. Epub 2015 Apr 2. J Agric Food Chem. 2015. PMID: 25797496
Omission experiments further confirmed (E)-2-nonenal as the key odorant and revealed the significance of (E)-2-octenal and 2-phenylethanol for the overall aroma of chixiang aroma-type liquor. 3-(Methylthio)-1-propanol (methionol), diethyl 1,7-heptanedioate (diethyl pimelate), die …
Omission experiments further confirmed (E)-2-nonenal as the key odorant and revealed the significance of (E)-2-octenal and 2-phenylethanol f …
Safety assessment of azelaic acid and its derivatives entrapped in nanovesicles.
Panyosak A, Manosroi J, Rojanasakul Y, Manosroi A. Panyosak A, et al. Hum Exp Toxicol. 2009 Jun;28(6-7):387-92. doi: 10.1177/0960327109105164. Hum Exp Toxicol. 2009. PMID: 19755450
The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was improved to diethyl azelate (DA) by esterification with Fischer reaction. AA, AACD and DA were entrapped in liposomes and nios …
The hydrophilic property of AA was modified by complexing AA with hydroxypropyl-beta-cyclodextrin (AACD). The lipophilic property of AA was …
Characteristics and anti-proliferative activity of azelaic acid and its derivatives entrapped in bilayer vesicles in cancer cell lines.
Manosroi A, Panyosak A, Rojanasakul Y, Manosroi J. Manosroi A, et al. J Drug Target. 2007 Jun;15(5):334-41. doi: 10.1080/10611860701349315. J Drug Target. 2007. PMID: 17541842
The hydrophilicity and lipophilicity of azelaic acid (AA) were modified to diethyl azelate (DA) which was synthesized by Fisher esterification reaction and identified by IR, MS and (1)H NMR and to azelaic acid-beta-cyclodextrin complex (AACD) which was prepared by i …
The hydrophilicity and lipophilicity of azelaic acid (AA) were modified to diethyl azelate (DA) which was synthesized by Fishe …
11 results