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GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas.
Majzner RG, Ramakrishna S, Yeom KW, Patel S, Chinnasamy H, Schultz LM, Richards RM, Jiang L, Barsan V, Mancusi R, Geraghty AC, Good Z, Mochizuki AY, Gillespie SM, Toland AMS, Mahdi J, Reschke A, Nie EH, Chau IJ, Rotiroti MC, Mount CW, Baggott C, Mavroukakis S, Egeler E, Moon J, Erickson C, Green S, Kunicki M, Fujimoto M, Ehlinger Z, Reynolds W, Kurra S, Warren KE, Prabhu S, Vogel H, Rasmussen L, Cornell TT, Partap S, Fisher PG, Campen CJ, Filbin MG, Grant G, Sahaf B, Davis KL, Feldman SA, Mackall CL, Monje M. Majzner RG, et al. Nature. 2022 Mar;603(7903):934-941. doi: 10.1038/s41586-022-04489-4. Epub 2022 Feb 7. Nature. 2022. PMID: 35130560 Free PMC article. Clinical Trial.
Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system(1). ...Pro-inflammatory cytokine levels were increased in the plasma and cere …
Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are unive …
Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience.
Del Baldo G, Carai A, Abbas R, Cacchione A, Vinci M, Di Ruscio V, Colafati GS, Rossi S, Diomedi Camassei F, Maestro N, Temelso S, Pericoli G, De Billy E, Giovannoni I, Carboni A, Rinelli M, Agolini E, Mackay A, Jones C, Chiesa S, Balducci M, Locatelli F, Mastronuzzi A. Del Baldo G, et al. Ther Adv Med Oncol. 2022 Sep 6;14:17588359221113693. doi: 10.1177/17588359221113693. eCollection 2022. Ther Adv Med Oncol. 2022. PMID: 36090803 Free PMC article.
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of less than 12 months after diagnosis. ...METHODS: In this study, we present a single-center experience in treating DIPG patients …
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of le …
Diffuse intrinsic pontine glioma biopsy: a single institution experience.
Wang ZJ, Rao L, Bhambhani K, Miller K, Poulik J, Altinok D, Sood S. Wang ZJ, et al. Pediatr Blood Cancer. 2015 Jan;62(1):163-5. doi: 10.1002/pbc.25224. Epub 2014 Sep 27. Pediatr Blood Cancer. 2015. PMID: 25263768 Free article. Clinical Trial.
Tumor biopsy is rarely performed in diffuse intrinsic pontine glioma (DIPG) due to the presumed risk of surgical complications, although data on the surgery related morbidity of DIPG biopsy is sparse. ...No surgery related mortality or pe …
Tumor biopsy is rarely performed in diffuse intrinsic pontine glioma (DIPG) due to the presumed risk of s …
Robot-Assisted Stereotactic Biopsy of Diffuse Intrinsic Pontine Glioma: A Single-Center Experience.
Carai A, Mastronuzzi A, De Benedictis A, Messina R, Cacchione A, Miele E, Randi F, Esposito G, Trezza A, Colafati GS, Savioli A, Locatelli F, Marras CE. Carai A, et al. World Neurosurg. 2017 May;101:584-588. doi: 10.1016/j.wneu.2017.02.088. Epub 2017 Feb 27. World Neurosurg. 2017. PMID: 28254596
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with a dismal prognosis. ...CONCLUSIONS: Pontine biopsy for DIPG is a safe procedure in selected centers. The advantages of the single-session procedure we de …
BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with a dismal prognosis. ...CONCLUSIONS …
Single institution experience in re-irradiation of biopsy-proven diffuse intrinsic pontine gliomas.
Zamora PL, Miller SR, Kovoor JJ. Zamora PL, et al. Childs Nerv Syst. 2021 Aug;37(8):2539-2543. doi: 10.1007/s00381-021-05195-8. Epub 2021 May 10. Childs Nerv Syst. 2021. PMID: 33973056
OBJECTIVES: Diffuse intrinsic pontine glioma (DIPG) is the leading cause of death from CNS tumors in children. ...The objective of this study was to review and report our institutional experience with re-irradiation of patients with bi …
OBJECTIVES: Diffuse intrinsic pontine glioma (DIPG) is the leading cause of death from CNS tumors in children. . …
Hypofractionated radiotherapy in the treatment of diffuse intrinsic pontine glioma in children: a single institution's experience.
Negretti L, Bouchireb K, Levy-Piedbois C, Habrand JL, Dhermain F, Kalifa C, Grill J, Dufour C. Negretti L, et al. J Neurooncol. 2011 Sep;104(3):773-7. doi: 10.1007/s11060-011-0542-4. Epub 2011 Feb 17. J Neurooncol. 2011. PMID: 21327862
We report herein our institutional experience in the treatment of diffuse intrinsic pontine glioma (DIPG) with a hypofractionated external-beam radiotherapy schedule. ...
We report herein our institutional experience in the treatment of diffuse intrinsic pontine glioma …
Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety.
Vitanza NA, Ronsley R, Choe M, Henson C, Breedt M, Barrios-Anderson A, Wein A, Brown C, Beebe A, Kong A, Kirkey D, Lee BM, Leary SES, Crotty EE, Hoeppner C, Holtzclaw S, Wilson AL, Gustafson JA, Foster JB, Iliff JJ, Goldstein HE, Browd SR, Lee A, Ojemann JG, Pinto N, Gust J, Gardner RA, Jensen MC, Hauptman JS, Park JR. Vitanza NA, et al. Neoplasia. 2023 Feb;36:100870. doi: 10.1016/j.neo.2022.100870. Epub 2023 Jan 3. Neoplasia. 2023. PMID: 36599192 Free PMC article.
Based on adoptive cellular therapy's clinical success against childhood leukemia and the preclinical efficacy against pediatric CNS tumors, chimeric antigen receptor (CAR) T cells offer hope of improving outcomes for recurrent tumors and universally fatal diseases such as diff …
Based on adoptive cellular therapy's clinical success against childhood leukemia and the preclinical efficacy against pediatric CNS tumors, …
Addition of Multimodal Immunotherapy to Combination Treatment Strategies for Children with DIPG: A Single Institution Experience.
Van Gool SW, Makalowski J, Bonner ER, Feyen O, Domogalla MP, Prix L, Schirrmacher V, Nazarian J, Stuecker W. Van Gool SW, et al. Medicines (Basel). 2020 May 19;7(5):29. doi: 10.3390/medicines7050029. Medicines (Basel). 2020. PMID: 32438648 Free PMC article.
Background: The prognosis of children with diffuse intrinsic pontine glioma (DIPG) remains dismal despite radio- and chemotherapy or molecular-targeted therapy. ...In the case of 16 patients, histone H3K27M mutation was confirmed by analysis of biop …
Background: The prognosis of children with diffuse intrinsic pontine glioma (DIPG) remains dismal despite radio- …
Immune checkpoint inhibition for pediatric patients with recurrent/refractory CNS tumors: a single institution experience.
Cacciotti C, Choi J, Alexandrescu S, Zimmerman MA, Cooney TM, Chordas C, Clymer J, Chi S, Yeo KK. Cacciotti C, et al. J Neurooncol. 2020 Aug;149(1):113-122. doi: 10.1007/s11060-020-03578-6. Epub 2020 Jul 5. J Neurooncol. 2020. PMID: 32627129 Clinical Trial.
INTRODUCTION: Immune checkpoint inhibition through PD-1 and CTLA-4 blockade has shown efficacy in some adult malignancies and generated interest in pediatrics, including central nervous system (CNS) tumors. We describe our experience with immune checkpoint inhibition in re …
INTRODUCTION: Immune checkpoint inhibition through PD-1 and CTLA-4 blockade has shown efficacy in some adult malignancies and generated inte …
First clinical experience with DRD2/3 antagonist ONC201 in H3 K27M-mutant pediatric diffuse intrinsic pontine glioma: a case report.
Hall MD, Odia Y, Allen JE, Tarapore R, Khatib Z, Niazi TN, Daghistani D, Schalop L, Chi AS, Oster W, Mehta MP. Hall MD, et al. J Neurosurg Pediatr. 2019 Apr 5;23(6):719-725. doi: 10.3171/2019.2.PEDS18480. J Neurosurg Pediatr. 2019. PMID: 30952114
Diffuse intrinsic pontine gliomas (DIPGs) frequently harbor the histone H3 K27M mutation. ...One pediatric patient (a 10-year-old girl) with H3 K27M-mutant DIPG was enrolled in an investigator-initiated, IRB-approved compassionate-use study and began singl …
Diffuse intrinsic pontine gliomas (DIPGs) frequently harbor the histone H3 K27M mutation. ...One pediatric patient (a 1 …
12 results