Ding K - Search Results

1

A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis and sensitizes lung cancer cells to chemotherapy.

Sun SH, Zheng M, Ding K, Wang S, Sun Y. Sun SH, et al. Among authors: ding k. Cancer Biol Ther. 2008 Jun;7(6):845-52. doi: 10.4161/cbt.7.6.5841. Epub 2008 Mar 5. Cancer Biol Ther. 2008. PMID: 18340116

2

Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.

Ji M, Chen J, Ding K, Wu X, Varady J, Levant B, Wang S. Ji M, et al. Among authors: ding k. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1701-5. doi: 10.1016/j.bmcl.2005.01.037. Bioorg Med Chem Lett. 2005. PMID: 15745825

3

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands.

Ding K, Chen J, Ji M, Wu X, Varady J, Yang CY, Lu Y, Deschamps JR, Levant B, Wang S. Ding K, et al. J Med Chem. 2005 May 5;48(9):3171-81. doi: 10.1021/jm049031l. J Med Chem. 2005. PMID: 15857123

4

Structure-based design of potent non-peptide MDM2 inhibitors.

Ding K, Lu Y, Nikolovska-Coleska Z, Qiu S, Ding Y, Gao W, Stuckey J, Krajewski K, Roller PP, Tomita Y, Parrish DA, Deschamps JR, Wang S. Ding K, et al. Among authors: ding y. J Am Chem Soc. 2005 Jul 27;127(29):10130-1. doi: 10.1021/ja051147z. J Am Chem Soc. 2005. PMID: 16028899

5

Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility.

Chen J, Ding K, Levant B, Wang S. Chen J, et al. Among authors: ding k. Bioorg Med Chem Lett. 2006 Jan 15;16(2):443-6. doi: 10.1016/j.bmcl.2005.09.053. Epub 2005 Nov 14. Bioorg Med Chem Lett. 2006. PMID: 16290142

6

Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

Ding K, Lu Y, Nikolovska-Coleska Z, Wang G, Qiu S, Shangary S, Gao W, Qin D, Stuckey J, Krajewski K, Roller PP, Wang S. Ding K, et al. J Med Chem. 2006 Jun 15;49(12):3432-5. doi: 10.1021/jm051122a. J Med Chem. 2006. PMID: 16759082

7

A novel Bcl-2 small molecule inhibitor 4-(3-methoxy-phenylsulfannyl)-7-nitro-benzofurazan-3-oxide (MNB)-induced apoptosis in leukemia cells.

Zhang M, Ling Y, Yang CY, Liu H, Wang R, Wu X, Ding K, Zhu F, Griffith BN, Mohammad RM, Wang S, Yang D. Zhang M, et al. Among authors: ding k. Ann Hematol. 2007 Jul;86(7):471-81. doi: 10.1007/s00277-007-0288-4. Epub 2007 Mar 30. Ann Hematol. 2007. PMID: 17396262

8

Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.

Tang G, Ding K, Nikolovska-Coleska Z, Yang CY, Qiu S, Shangary S, Wang R, Guo J, Gao W, Meagher J, Stuckey J, Krajewski K, Jiang S, Roller PP, Wang S. Tang G, et al. Among authors: ding k. J Med Chem. 2007 Jul 12;50(14):3163-6. doi: 10.1021/jm070383c. Epub 2007 Jun 7. J Med Chem. 2007. PMID: 17552510 Free PMC article.

9

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition.

Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, Nikolovska-Coleska Z, Ding K, Wang G, Chen J, Bernard D, Zhang J, Lu Y, Gu Q, Shah RB, Pienta KJ, Ling X, Kang S, Guo M, Sun Y, Yang D, Wang S. Shangary S, et al. Among authors: ding k. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8. doi: 10.1073/pnas.0708917105. Epub 2008 Mar 3. Proc Natl Acad Sci U S A. 2008. PMID: 18316739 Free PMC article.

10

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer.

Shangary S, Ding K, Qiu S, Nikolovska-Coleska Z, Bauer JA, Liu M, Wang G, Lu Y, McEachern D, Bernard D, Bradford CR, Carey TE, Wang S. Shangary S, et al. Among authors: ding k. Mol Cancer Ther. 2008 Jun;7(6):1533-42. doi: 10.1158/1535-7163.MCT-08-0140. Mol Cancer Ther. 2008. PMID: 18566224 Free PMC article.

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