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Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets.
Saito A, Higgins M, Zheng S, Li W, Ojima I, Dinkova-Kostova AT, Honda T. Saito A, et al. Bioorg Med Chem Lett. 2013 Oct 15;23(20):5540-3. doi: 10.1016/j.bmcl.2013.08.058. Epub 2013 Aug 21. Bioorg Med Chem Lett. 2013. PMID: 24018193
Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.
Zheng S, Huang JT, Knatko EV, Sharp S, Higgins M, Ojima I, Dinkova-Kostova AT, Honda T. Zheng S, et al. J Labelled Comp Radiopharm. 2014 Aug;57(10):606-10. doi: 10.1002/jlcr.3230. Epub 2014 Sep 5. J Labelled Comp Radiopharm. 2014. PMID: 25196444
Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.
Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT. Knatko EV, et al. Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24. Cancer Prev Res (Phila). 2015. PMID: 25804610 Free PMC article.
Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.
Kostov RV, Knatko EV, McLaughlin LA, Henderson CJ, Zheng S, Huang JT, Honda T, Dinkova-Kostova AT. Kostov RV, et al. Biochem Biophys Res Commun. 2015 Sep 25;465(3):402-7. doi: 10.1016/j.bbrc.2015.08.016. Epub 2015 Aug 8. Biochem Biophys Res Commun. 2015. PMID: 26265043 Free PMC article.
191 results