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Page 1
DISC1 as a therapeutic target for mental illnesses.
Hikida T, Gamo NJ, Sawa A. Hikida T, et al. Expert Opin Ther Targets. 2012 Dec;16(12):1151-60. doi: 10.1517/14728222.2012.719879. Epub 2012 Nov 6. Expert Opin Ther Targets. 2012. PMID: 23130881 Free PMC article. Review.
EXPERT OPINION: Modulation of DISC1 stability and post-transcriptional modifications may be key targets to address DISC1-related pathology. In addition, modulation of DISC1 interactors and the mechanisms of their interactions with DISC1 may also provid …
EXPERT OPINION: Modulation of DISC1 stability and post-transcriptional modifications may be key targets to address DISC1-relat …
Mutations in DISC1 alter IP(3)R and voltage-gated Ca(2+) channel functioning, implications for major mental illness.
Rittenhouse AR, Ortiz-Miranda S, Jurczyk A. Rittenhouse AR, et al. Neuronal Signal. 2021 Dec 7;5(4):NS20180122. doi: 10.1042/NS20180122. eCollection 2021 Dec. Neuronal Signal. 2021. PMID: 34956649 Free PMC article. Review.
It also serves critical roles that underlie cognitive functioning in adult central neurons. Here we summarize DISC1's general properties and discuss its use as a model system for understanding major mental illnesses (MMIs). ...We also review DISC1's ro …
It also serves critical roles that underlie cognitive functioning in adult central neurons. Here we summarize DISC1's general …
The TRAX, DISC1, and GSK3 complex in mental disorders and therapeutic interventions.
Weng YT, Chien T, Kuan II, Chern Y. Weng YT, et al. J Biomed Sci. 2018 Oct 4;25(1):71. doi: 10.1186/s12929-018-0473-x. J Biomed Sci. 2018. PMID: 30285728 Free PMC article. Review.
DISC1 binds directly to GSK3 and modulates many cellular functions by negatively inhibiting GSK3 activity. ...A recent study demonstrated that a neighboring gene of DISC1, translin-associated factor X (TRAX), binds to the DISC1/GSK3beta complex and at least p …
DISC1 binds directly to GSK3 and modulates many cellular functions by negatively inhibiting GSK3 activity. ...A recent study demonstr …
Gene polymorphisms of DISC1 is associated with schizophrenia: Evidence from a meta-analysis.
Wang HY, Liu Y, Yan JW, Hu XL, Zhu DM, Xu XT, Li XS. Wang HY, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:64-73. doi: 10.1016/j.pnpbp.2017.10.008. Epub 2017 Oct 12. Prog Neuropsychopharmacol Biol Psychiatry. 2018. PMID: 29031911 Review.
In subgroups of ethnicity, DISC1 polymorphisms (rs821616 and rs821597) was associated with susceptibility to SCZ among the Chinese population (for rs821616: TT+AT vs. ...CONCLUSIONS: DISC1 polymorphisms increased a risk of SCZ, especially in the Chinese population. …
In subgroups of ethnicity, DISC1 polymorphisms (rs821616 and rs821597) was associated with susceptibility to SCZ among the Chinese po …
Zebrafish as a model to investigate the CRH axis and interactions with DISC1.
Eachus H, Ryu S, Placzek M, Wood J. Eachus H, et al. Curr Opin Endocr Metab Res. 2022 Oct;26:100383. doi: 10.1016/j.coemr.2022.100383. Curr Opin Endocr Metab Res. 2022. PMID: 36632608 Free PMC article. Review.
In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizophrenia 1 (DISC1) mutant zebrafish have blunted stress responses and can be used to model human stress disorders. We propose that D …
In this article, we review how in vivo studies in zebrafish have advanced knowledge of the neurobiology of CRH neurons. Disrupted-in-schizop …
DISC1 at 10: connecting psychiatric genetics and neuroscience.
Porteous DJ, Millar JK, Brandon NJ, Sawa A. Porteous DJ, et al. Trends Mol Med. 2011 Dec;17(12):699-706. doi: 10.1016/j.molmed.2011.09.002. Epub 2011 Oct 19. Trends Mol Med. 2011. PMID: 22015021 Free PMC article. Review.
Through in vitro experiments and mouse models, DISC1 has been firmly established as a genetic risk factor for a spectrum of psychiatric illness. ...DISC1 is a pathfinder for understanding psychopathology, brain development, signaling and circuitry. ...
Through in vitro experiments and mouse models, DISC1 has been firmly established as a genetic risk factor for a spectrum of psychiatr …
DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity.
Devine MJ, Norkett R, Kittler JT. Devine MJ, et al. J Physiol. 2016 Oct 1;594(19):5459-69. doi: 10.1113/JP272187. Epub 2016 Jun 12. J Physiol. 2016. PMID: 27121900 Free PMC article. Review.
This communication is impaired in psychiatric disease, and ongoing studies have proposed that Disrupted in schizophrenia 1 (DISC1) is an important genetic risk factor for these disorders. The mechanisms by which DISC1 dysfunction might increase propensity to psychia …
This communication is impaired in psychiatric disease, and ongoing studies have proposed that Disrupted in schizophrenia 1 (DISC1) is …
Role of DISC1 in Neuronal Trafficking and its Implication in Neuropsychiatric Manifestation and Neurotherapeutics.
Tomoda T, Hikida T, Sakurai T. Tomoda T, et al. Neurotherapeutics. 2017 Jul;14(3):623-629. doi: 10.1007/s13311-017-0556-5. Neurotherapeutics. 2017. PMID: 28664299 Free PMC article. Review.
Although DISC1 is not a risk gene for sporadic cases of specific psychiatric disorders defined by categorical diagnostic criteria (e.g., schizophrenia and major depressive disorder), DISC1 is now regarded as an important molecular lead to decipher molecular patholog …
Although DISC1 is not a risk gene for sporadic cases of specific psychiatric disorders defined by categorical diagnostic criteria (e. …
Mechanisms underlying the role of DISC1 in synaptic plasticity.
Tropea D, Hardingham N, Millar K, Fox K. Tropea D, et al. J Physiol. 2018 Jul;596(14):2747-2771. doi: 10.1113/JP274330. J Physiol. 2018. PMID: 30008190 Free PMC article. Review.
It concentrates on DISC1's role in interacting with synaptic proteins, controlling dendritic structure and cellular trafficking of mRNA, synaptic vesicles and mitochondria. ...While the multiplicity of DISC1 protein interactions makes it difficult to pinpoint …
It concentrates on DISC1's role in interacting with synaptic proteins, controlling dendritic structure and cellular traffickin …
DISC1 as a prognostic biomarker correlated with immune infiltrates in gastric cancer.
Zheng S, Chen Y, Yu S, Weng C, Lin N, Luo Z, Wang Y, Xiong P, Teng Z, Wang Y, Zhao H, Xiao C. Zheng S, et al. Heliyon. 2023 Mar 29;9(4):e15058. doi: 10.1016/j.heliyon.2023.e15058. eCollection 2023 Apr. Heliyon. 2023. PMID: 37151698 Free PMC article.
Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how DISC1 might contribute to the development of tumors and immune responses. ...Furthermore, the higher the DISC1 expression, the l …
Multiple mental diseases could arise in people who have the disrupted in schizophrenia 1 (DISC1) gene. However, it was unknown how …
1,063 results