Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1998 1
1999 4
2000 15
2001 8
2002 21
2003 20
2004 17
2005 19
2006 26
2007 40
2008 31
2009 41
2010 37
2011 41
2012 40
2013 57
2014 61
2015 48
2016 62
2017 66
2018 63
2019 75
2020 65
2021 72
2022 63
2023 66
2024 34

Text availability

Article attribute

Article type

Publication date

Search Results

976 results

Results by year

Filters applied: . Clear all
Page 1
DMRT1 regulates human germline commitment.
Irie N, Lee SM, Lorenzi V, Xu H, Chen J, Inoue M, Kobayashi T, Sancho-Serra C, Drousioti E, Dietmann S, Vento-Tormo R, Song CX, Surani MA. Irie N, et al. Nat Cell Biol. 2023 Oct;25(10):1439-1452. doi: 10.1038/s41556-023-01224-7. Epub 2023 Sep 14. Nat Cell Biol. 2023. PMID: 37709822 Free PMC article.
Moreover, the induction of DMRT1 and SOX17 in PGC-like cells promoted epigenetic resetting with striking global enrichment of 5-hydroxymethylcytosine and locus-specific loss of 5-methylcytosine at DMRT1 binding sites and the expression of DAZL representing DNA methy …
Moreover, the induction of DMRT1 and SOX17 in PGC-like cells promoted epigenetic resetting with striking global enrichment of 5-hydro …
DMRT1: An Ancient Sexual Regulator Required for Human Gonadogenesis.
Zarkower D, Murphy MW. Zarkower D, et al. Sex Dev. 2022;16(2-3):112-125. doi: 10.1159/000518272. Epub 2021 Sep 1. Sex Dev. 2022. PMID: 34515237 Free PMC article. Review.
Moreover, ectopic DMRT1 can reprogram differentiated female granulosa cells into male Sertoli-like cells. The ability of DMRT1 to control sexual cell fate likely derives from at least 3 properties. ...
Moreover, ectopic DMRT1 can reprogram differentiated female granulosa cells into male Sertoli-like cells. The ability of DMRT1 …
DMRT1 is a testis-determining gene in rabbits and is also essential for female fertility.
Dujardin E, André M, Dewaele A, Mandon-Pépin B, Poulat F, Frambourg A, Thépot D, Jouneau L, Jolivet G, Pailhoux E, Pannetier M. Dujardin E, et al. Elife. 2023 Oct 17;12:RP89284. doi: 10.7554/eLife.89284. Elife. 2023. PMID: 37847154 Free PMC article.
Second, we highlighted another function of DMRT1 in the germline since XX and XY DMRT1(-/-) ovaries did not undergo meiosis and folliculogenesis. XX DMRT1(-/-) adult females were sterile, showing that DMRT1 is also crucial for female fertility. ...
Second, we highlighted another function of DMRT1 in the germline since XX and XY DMRT1(-/-) ovaries did not undergo meiosis an …
DMRT1 drives the human germline forward.
Lu Y, Yuan P, Qiao J. Lu Y, et al. Nat Cell Biol. 2023 Oct;25(10):1408-1410. doi: 10.1038/s41556-023-01196-8. Nat Cell Biol. 2023. PMID: 37709821 No abstract available.
Transcription factor Dmrt1 triggers the SPRY1-NF-kappaB pathway to maintain testicular immune homeostasis and male fertility.
Zhang MF, Wan SC, Chen WB, Yang DH, Liu WQ, Li BL, Aierken A, Du XM, Li YX, Wu WP, Yang XC, Wei YD, Li N, Peng S, Li XL, Li GP, Hua JL. Zhang MF, et al. Zool Res. 2023 May 18;44(3):505-521. doi: 10.24272/j.issn.2095-8137.2022.440. Zool Res. 2023. PMID: 37070575 Free PMC article.
Knockdown of Dmrt1 in male mice inhibited spermatogenesis with a broad inflammatory response in seminiferous tubules and led to the loss of spermatogenic epithelial cells. Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq) revealed that Dmr …
Knockdown of Dmrt1 in male mice inhibited spermatogenesis with a broad inflammatory response in seminiferous tubules and led to the l …
DMRT1 gene disruption alone induces incomplete gonad feminization in chicken.
Lee HJ, Seo M, Choi HJ, Rengaraj D, Jung KM, Park JS, Lee KY, Kim YM, Park KJ, Han ST, Lee KH, Yao HH, Han JY. Lee HJ, et al. FASEB J. 2021 Sep;35(9):e21876. doi: 10.1096/fj.202100902R. FASEB J. 2021. PMID: 34449112 Free PMC article.
Knockdown and overexpression studies identified doublesex and mab-3-related transcription factor 1 (DMRT1) as the testis-determining gene in chicken. However, the detailed effects of DMRT1 gene disruption from embryonic to adult development are not clear. ...Subsequ …
Knockdown and overexpression studies identified doublesex and mab-3-related transcription factor 1 (DMRT1) as the testis-determining …
Dmrt1 genes at the crossroads: a widespread and central class of sexual development factors in fish.
Herpin A, Schartl M. Herpin A, et al. FEBS J. 2011 Apr;278(7):1010-9. doi: 10.1111/j.1742-4658.2011.08030.x. Epub 2011 Feb 25. FEBS J. 2011. PMID: 21281449 Free article. Review.
This minireview aims at distilling the current knowledge of fish dmrt1s, in terms of expression and regulation. It is shown how gonadal identities correlate with dimorphic dmrt1 expression in gonochoristic and hermaphroditic fish species. It is also described how sex stero …
This minireview aims at distilling the current knowledge of fish dmrt1s, in terms of expression and regulation. It is shown how gonadal iden …
Sex determination and maintenance: the role of DMRT1 and FOXL2.
Huang S, Ye L, Chen H. Huang S, et al. Asian J Androl. 2017 Nov-Dec;19(6):619-624. doi: 10.4103/1008-682X.194420. Asian J Androl. 2017. PMID: 28091399 Free PMC article. Review.
These studies have shown that two key genes, doublesex and mad-3 related transcription factor 1 (Dmrt1) and forkhead box L2 (Foxl2), function in a Yin and Yang relationship to maintain the fates of testes or ovaries in adult mammals, and that mutations in either gene might …
These studies have shown that two key genes, doublesex and mad-3 related transcription factor 1 (Dmrt1) and forkhead box L2 (Foxl2), …
DMRT1-mediated regulation of TOX3 modulates expansion of the gonadal steroidogenic cell lineage in the chicken embryo.
Estermann MA, Major AT, Smith CA. Estermann MA, et al. Development. 2023 Mar 1;150(5):dev201466. doi: 10.1242/dev.201466. Epub 2023 Mar 9. Development. 2023. PMID: 36794750 Free PMC article.
TOX3 overexpression in male and female gonads resulted in a significant decline in CYP17A1-positive steroidogenic cells. In ovo knockdown of the testis determinant DMRT1 in male gonads resulted in a downregulation of TOX3 expression. Conversely, DMRT1 overexpression …
TOX3 overexpression in male and female gonads resulted in a significant decline in CYP17A1-positive steroidogenic cells. In ovo knockdown of …
DMRT1 keeps masculinity intact.
DeFalco T. DeFalco T. Dev Cell. 2014 Jun 9;29(5):503-504. doi: 10.1016/j.devcel.2014.05.015. Dev Cell. 2014. PMID: 24914556 Free article.
In this issue of Developmental Cell, Minkina et al. (2014) now show that the transcriptional regulator DMRT1 actively prevents postnatal male-to-female sex reversal by blocking the activation of retinoid-signaling-dependent feminization genes....
In this issue of Developmental Cell, Minkina et al. (2014) now show that the transcriptional regulator DMRT1 actively prevents postna …
976 results