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LncRNA Dnmt3aos regulates Dnmt3a expression leading to aberrant DNA methylation in macrophage polarization.
Li X, Zhang Y, Pei W, Zhang M, Yang H, Zhong M, Kong X, Xu Y, Zhu X, Chen T, Ye J, Lv K. Li X, et al. FASEB J. 2020 Apr;34(4):5077-5091. doi: 10.1096/fj.201902379R. Epub 2020 Feb 13. FASEB J. 2020. PMID: 32052888
Functional experiments further confirmed that Dnmt3aos were highly expressed in M(IL-4) macrophages and participated in the regulation of Dnmt3a expression, and played a key role in macrophage polarization. The DNA methylation profiles between the Dnmt3aos knockdown …
Functional experiments further confirmed that Dnmt3aos were highly expressed in M(IL-4) macrophages and participated in the regulatio …
Exosome membrane-modified M2 macrophages targeted nanomedicine: Treatment for allergic asthma.
Pei W, Li X, Bi R, Zhang X, Zhong M, Yang H, Zhang Y, Lv K. Pei W, et al. J Control Release. 2021 Oct 10;338:253-267. doi: 10.1016/j.jconrel.2021.08.024. Epub 2021 Aug 19. J Control Release. 2021. PMID: 34418524 Free article.
The resulting exosome membrane coated PLGA@Dnmt3aos(smart silencer) (EM-PLGA@Dnmt3aos(smart silencer)) was administered intravenously into Der f1-induced asthma mice, which was followed by the investigation of therapeutic outcomes and the mechanism in vivo. RESULTS: …
The resulting exosome membrane coated PLGA@Dnmt3aos(smart silencer) (EM-PLGA@Dnmt3aos(smart silencer)) was administered intrav …