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Successful treatment of hairy cell leukemia variant with rituximab.
Narat S, Gandla J, Dogan A, Mehta A. Narat S, et al. Leuk Lymphoma. 2005 Aug;46(8):1229-32. doi: 10.1080/10428190500083433. Leuk Lymphoma. 2005. PMID: 16085567
We report a case of a 53-year-old man who had refractory thrombocytopenia and lymphocytosis for 8 years. Investigations and analysis of spleen and bone marrow revealed a diagnosis of HCL variant. He opted for treatment with rituximab, a chimeric monocl …
We report a case of a 53-year-old man who had refractory thrombocytopenia and lymphocytosis for 8 years. Investigations and an …
Inhibition of Syk protein tyrosine kinase induces apoptosis and blocks proliferation in T-cell non-Hodgkin's lymphoma cell lines.
Wilcox RA, Sun DX, Novak A, Dogan A, Ansell SM, Feldman AL. Wilcox RA, et al. Leukemia. 2010 Jan;24(1):229-32. doi: 10.1038/leu.2009.198. Epub 2009 Sep 24. Leukemia. 2010. PMID: 19776763 Free PMC article. No abstract available.
Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas.
Feldman AL, Law M, Remstein ED, Macon WR, Erickson LA, Grogg KL, Kurtin PJ, Dogan A. Feldman AL, et al. Leukemia. 2009 Mar;23(3):574-80. doi: 10.1038/leu.2008.320. Epub 2008 Nov 6. Leukemia. 2009. PMID: 18987657 Free PMC article.
These findings identified IRF4 translocations as a novel recurrent genetic abnormality in PTCLs. Cytotoxic PTCL-Us involving bone marrow and skin and containing IRF4/TCRA translocations might represent a distinct clinicopathologic entity. ...Further, due to its invo …
These findings identified IRF4 translocations as a novel recurrent genetic abnormality in PTCLs. Cytotoxic PTCL-Us involving bone mar …
Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas.
Feldman AL, Sun DX, Law ME, Novak AJ, Attygalle AD, Thorland EC, Fink SR, Vrana JA, Caron BL, Morice WG, Remstein ED, Grogg KL, Kurtin PJ, Macon WR, Dogan A. Feldman AL, et al. Leukemia. 2008 Jun;22(6):1139-43. doi: 10.1038/leu.2008.77. Epub 2008 Apr 10. Leukemia. 2008. PMID: 18401419 Free PMC article.
Overexpression of Syk, phosphorylation of its Y525/526 residues and the availability of orally available Syk inhibitors suggest that Syk merits further evaluation as a candidate target for pharmacologic PTK inhibition in patients with PTCL....
Overexpression of Syk, phosphorylation of its Y525/526 residues and the availability of orally available Syk inhibitors suggest that Syk mer …
Novel FISH probes designed to detect IGK-MYC and IGL-MYC rearrangements in B-cell lineage malignancy identify a new breakpoint cluster region designated BVR2.
Einerson RR, Law ME, Blair HE, Kurtin PJ, McClure RF, Ketterling RP, Flynn HC, Dogan A, Remstein ED. Einerson RR, et al. Leukemia. 2006 Oct;20(10):1790-9. doi: 10.1038/sj.leu.2404340. Epub 2006 Aug 3. Leukemia. 2006. PMID: 16888615
Seven specimens, all of which lacked MYC rearrangements using a commercial IGH/MYC D-FISH probe, were found to have 8q24 breakpoints within a cluster region >350-645 kb 3' from MYC, provisionally designated as Burkitt variant rearrangement region 2 (BVR2). FISH i …
Seven specimens, all of which lacked MYC rearrangements using a commercial IGH/MYC D-FISH probe, were found to have 8q24 breakpoints …
The prevalence of IG translocations and 7q32 deletions in splenic marginal zone lymphoma.
Remstein ED, Law M, Mollejo M, Piris MA, Kurtin PJ, Dogan A. Remstein ED, et al. Leukemia. 2008 Jun;22(6):1268-72. doi: 10.1038/sj.leu.2405027. Epub 2007 Nov 8. Leukemia. 2008. PMID: 17989713 No abstract available.
Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: implications for epigenetic therapy.
Witzig TE, Hu G, Offer SM, Wellik LE, Han JJ, Stenson MJ, Dogan A, Diasio RB, Gupta M. Witzig TE, et al. Leukemia. 2014 Jan;28(1):147-54. doi: 10.1038/leu.2013.251. Epub 2013 Aug 27. Leukemia. 2014. PMID: 23979523 Free PMC article.
However, hypermethylation in 57% (21/37) of cases was found in a novel CpG island (CpG2) in P2. PTPN6 gene suppression was reversed by 5-aza-deoxycytidine (5-Aza), a DNA methyltransferase inhibitor, and the histone deacetylase inhibitor (HDACi) LBH589. ...The role o …
However, hypermethylation in 57% (21/37) of cases was found in a novel CpG island (CpG2) in P2. PTPN6 gene suppression was reversed b …
Clonal B cells in Waldenström's macroglobulinemia exhibit functional features of chronic active B-cell receptor signaling.
Argyropoulos KV, Vogel R, Ziegler C, Altan-Bonnet G, Velardi E, Calafiore M, Dogan A, Arcila M, Patel M, Knapp K, Mallek C, Hunter ZR, Treon SP, van den Brink MR, Palomba ML. Argyropoulos KV, et al. Leukemia. 2016 May;30(5):1116-25. doi: 10.1038/leu.2016.8. Epub 2016 Feb 12. Leukemia. 2016. PMID: 26867669 Free PMC article.
Nevertheless, the presence of chronic active B-cell receptor (BCR) signaling, a feature of multiple IgM+ B-NHL, remains a subject of speculation in WM. ...Finally, led by the high-signaling heterogeneity among WM samples, we generated patient-specific phosphosignatu …
Nevertheless, the presence of chronic active B-cell receptor (BCR) signaling, a feature of multiple IgM+ B-NHL, remains a subj …
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