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Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis.
Wring S, Gaukel E, Nare B, Jacobs R, Beaudet B, Bowling T, Mercer L, Bacchi C, Yarlett N, Randolph R, Parham R, Rewerts C, Platner J, Don R. Wring S, et al. Among authors: don r. Parasitology. 2014 Jan;141(1):104-18. doi: 10.1017/S003118201300098X. Epub 2013 Sep 5. Parasitology. 2014. PMID: 24007596 Free PMC article. Review.
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
Jacobs RT, Nare B, Wring SA, Orr MD, Chen D, Sligar JM, Jenks MX, Noe RA, Bowling TS, Mercer LT, Rewerts C, Gaukel E, Owens J, Parham R, Randolph R, Beaudet B, Bacchi CJ, Yarlett N, Plattner JJ, Freund Y, Ding C, Akama T, Zhang YK, Brun R, Kaiser M, Scandale I, Don R. Jacobs RT, et al. Among authors: don r. PLoS Negl Trop Dis. 2011 Jun;5(6):e1151. doi: 10.1371/journal.pntd.0001151. Epub 2011 Jun 28. PLoS Negl Trop Dis. 2011. PMID: 21738803 Free PMC article.
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