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Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors.
Wallace MB, Adams ME, Kanouni T, Mol CD, Dougan DR, Feher VA, O'Connell SM, Shi L, Halkowycz P, Dong Q. Wallace MB, et al. Among authors: dong q. Bioorg Med Chem Lett. 2010 Jul 15;20(14):4156-8. doi: 10.1016/j.bmcl.2010.05.058. Epub 2010 May 20. Bioorg Med Chem Lett. 2010. PMID: 20621728
Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK).
Lam B, Arikawa Y, Cramlett J, Dong Q, de Jong R, Feher V, Grimshaw CE, Farrell PJ, Hoffman ID, Jennings A, Jones B, Matuszkiewicz J, Miura J, Miyake H, Natala SR, Shi L, Takahashi M, Taylor E, Wyrick C, Yano J, Zalevsky J, Nie Z. Lam B, et al. Among authors: dong q. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-5950. doi: 10.1016/j.bmcl.2016.10.087. Epub 2016 Nov 2. Bioorg Med Chem Lett. 2016. PMID: 27839918
Discovery of novel orally bioavailable GPR40 agonists.
Lu H, Fei H, Yang F, Zheng S, Hu Q, Zhang L, Yuan J, Feng J, Sun P, Dong Q. Lu H, et al. Among authors: dong q. Bioorg Med Chem Lett. 2013 May 15;23(10):2920-4. doi: 10.1016/j.bmcl.2013.03.060. Epub 2013 Mar 26. Bioorg Med Chem Lett. 2013. PMID: 23582779
WITHDRAWN: Discovery of SHR1977: A highly potent and selective ROMK inhibitor.
Li X, Zhang Y, Chen Y, He W, Wan H, Zhang L, Hu Q, Feng J, Yuan J, Dong Q, Cao G, Zhang L, He F, Bai C, Tao W. Li X, et al. Among authors: dong q. Bioorg Med Chem Lett. 2016 Jun 27:S0960-894X(16)30683-7. doi: 10.1016/j.bmcl.2016.06.072. Online ahead of print. Bioorg Med Chem Lett. 2016. PMID: 27377326
5,346 results