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Conformational Dynamics and Allostery in Pyruvate Kinase.
Donovan KA, Zhu S, Liuni P, Peng F, Kessans SA, Wilson DJ, Dobson RC. Donovan KA, et al. J Biol Chem. 2016 Apr 22;291(17):9244-56. doi: 10.1074/jbc.M115.676270. Epub 2016 Feb 15. J Biol Chem. 2016. PMID: 26879751 Free PMC article.
The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana.
Oliver MR, Crowther JM, Leeman MM, Kessans SA, North RA, Donovan KA, Griffin MD, Suzuki H, Hudson AO, Kasanmascheff M, Dobson RC. Oliver MR, et al. Among authors: donovan ka. Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):663-8. doi: 10.1107/S2053230X14007699. Epub 2014 Apr 25. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24817733 Free PMC article.
Structure-function analyses of two plant meso-diaminopimelate decarboxylase isoforms reveal that active-site gating provides stereochemical control.
Crowther JM, Cross PJ, Oliver MR, Leeman MM, Bartl AJ, Weatherhead AW, North RA, Donovan KA, Griffin MDW, Suzuki H, Hudson AO, Kasanmascheff M, Dobson RCJ. Crowther JM, et al. Among authors: donovan ka. J Biol Chem. 2019 May 24;294(21):8505-8515. doi: 10.1074/jbc.RA118.006825. Epub 2019 Apr 8. J Biol Chem. 2019. PMID: 30962284 Free PMC article.
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions.
Gao Y, Jiang B, Kim H, Berberich MJ, Che J, Donovan KA, Hatcher JM, Huerta F, Kwiatkowski NP, Liu Y, Liuni PP, Metivier RJ, Murali VK, Nowak RP, Zhang T, Fischer ES, Gray NS, Jones LH. Gao Y, et al. Among authors: donovan ka. J Med Chem. 2023 Apr 27;66(8):5524-5535. doi: 10.1021/acs.jmedchem.2c01864. Epub 2023 Apr 10. J Med Chem. 2023. PMID: 37036171
Genomic and Biochemical Analysis of the Diaminopimelate and Lysine Biosynthesis Pathway in Verrucomicrobium spinosum: Identification and Partial Characterization of L,L-Diaminopimelate Aminotransferase and UDP-N-Acetylmuramoylalanyl-D-glutamyl-2,6-meso-Diaminopimelate Ligase.
Nachar VR, Savka FC, McGroty SE, Donovan KA, North RA, Dobson RC, Buckley LJ, Hudson AO. Nachar VR, et al. Among authors: donovan ka. Front Microbiol. 2012 May 25;3:183. doi: 10.3389/fmicb.2012.00183. eCollection 2012. Front Microbiol. 2012. PMID: 22783236 Free PMC article.
195 results