Dooley S - Search Results

1

Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma.

Sajadian SO, Ehnert S, Vakilian H, Koutsouraki E, Damm G, Seehofer D, Thasler W, Dooley S, Baharvand H, Sipos B, Nussler AK. Sajadian SO, et al. Among authors: dooley s. Clin Epigenetics. 2015 Sep 11;7(1):98. doi: 10.1186/s13148-015-0133-x. eCollection 2015. Clin Epigenetics. 2015. PMID: 26366235 Free PMC article.

2

Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice.

Hamzavi J, Ehnert S, Godoy P, Ciuclan L, Weng H, Mertens PR, Heuchel R, Dooley S. Hamzavi J, et al. Among authors: dooley s. J Cell Mol Med. 2008 Oct;12(5B):2130-44. doi: 10.1111/j.1582-4934.2008.00262.x. Epub 2008 Feb 4. J Cell Mol Med. 2008. PMID: 18266971 Free PMC article.

3

Blood monocyte-derived neohepatocytes as in vitro test system for drug metabolism.

Ehnert S, Nussler AK, Lehmann A, Dooley S. Ehnert S, et al. Among authors: dooley s. Drug Metab Dispos. 2008 Sep;36(9):1922-9. doi: 10.1124/dmd.108.020453. Epub 2008 Jun 16. Drug Metab Dispos. 2008. PMID: 18559486

4

Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage.

Dooley S, Hamzavi J, Ciuclan L, Godoy P, Ilkavets I, Ehnert S, Ueberham E, Gebhardt R, Kanzler S, Geier A, Breitkopf K, Weng H, Mertens PR. Dooley S, et al. Gastroenterology. 2008 Aug;135(2):642-59. doi: 10.1053/j.gastro.2008.04.038. Epub 2008 May 15. Gastroenterology. 2008. PMID: 18602923 Free article.

5

Neohepatocytes from alcoholics and controls express hepatocyte markers and display reduced fibrogenic TGF-ß/Smad3 signaling: advantage for cell transplantation?

Ehnert S, Knobeloch D, Blankenstein A, Müller A, Böcker U, Gillen S, Friess H, Thasler WE, Dooley S, Nussler AK. Ehnert S, et al. Among authors: dooley s. Alcohol Clin Exp Res. 2010 Apr;34(4):708-18. doi: 10.1111/j.1530-0277.2009.01140.x. Epub 2010 Jan 26. Alcohol Clin Exp Res. 2010. PMID: 20102559

6

TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I.

Ciuclan L, Ehnert S, Ilkavets I, Weng HL, Gaitantzi H, Tsukamoto H, Ueberham E, Meindl-Beinker NM, Singer MV, Breitkopf K, Dooley S. Ciuclan L, et al. Among authors: dooley s. J Hepatol. 2010 Mar;52(3):407-16. doi: 10.1016/j.jhep.2009.12.003. Epub 2010 Jan 6. J Hepatol. 2010. PMID: 20129692

7

TGF-β1 as possible link between loss of bone mineral density and chronic inflammation.

Ehnert S, Baur J, Schmitt A, Neumaier M, Lucke M, Dooley S, Vester H, Wildemann B, Stöckle U, Nussler AK. Ehnert S, et al. Among authors: dooley s. PLoS One. 2010 Nov 22;5(11):e14073. doi: 10.1371/journal.pone.0014073. PLoS One. 2010. PMID: 21124921 Free PMC article.

8

Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism.

Lin J, Schyschka L, Mühl-Benninghaus R, Neumann J, Hao L, Nussler N, Dooley S, Liu L, Stöckle U, Nussler AK, Ehnert S. Lin J, et al. Among authors: dooley s. Arch Toxicol. 2012 Jan;86(1):87-95. doi: 10.1007/s00204-011-0733-y. Epub 2011 Jul 7. Arch Toxicol. 2012. PMID: 21735230

9

L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF-β production and signalling.

Köppel H, Riedl E, Braunagel M, Sauerhoefer S, Ehnert S, Godoy P, Sternik P, Dooley S, Yard BA. Köppel H, et al. Among authors: dooley s. Nephrol Dial Transplant. 2011 Dec;26(12):3852-8. doi: 10.1093/ndt/gfr324. Epub 2011 Jul 12. Nephrol Dial Transplant. 2011. PMID: 21750159

10

Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?

Ehnert S, Zhao J, Pscherer S, Freude T, Dooley S, Kolk A, Stöckle U, Nussler AK, Hube R. Ehnert S, et al. Among authors: dooley s. BMC Med. 2012 Sep 7;10:101. doi: 10.1186/1741-7015-10-101. BMC Med. 2012. PMID: 22958403 Free PMC article.

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