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Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells.
Benedicto I, Carmona RM, Barettino A, Espinós-Estévez C, Gonzalo P, Nevado RM, de la Fuente-Pérez M, Andrés-Manzano MJ, González-Gómez C, Rolas L, Dorado B, Nourshargh S, Hamczyk MR, Andrés V. Benedicto I, et al. Among authors: dorado b. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2400752121. doi: 10.1073/pnas.2400752121. Epub 2024 Apr 22. Proc Natl Acad Sci U S A. 2024. PMID: 38648484 Free PMC article.
Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome.
Sánchez-López A, Espinós-Estévez C, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR, Macías Á, Del Campo L, Camafeita E, Vázquez J, Barkaway A, Rolas L, Nourshargh S, Dorado B, Benedicto I, Andrés V. Sánchez-López A, et al. Among authors: dorado b. Circulation. 2021 Nov 30;144(22):1777-1794. doi: 10.1161/CIRCULATIONAHA.121.055313. Epub 2021 Oct 25. Circulation. 2021. PMID: 34694158 Free PMC article.
Lamin A/C Ablation Restricted to Vascular Smooth Muscle Cells, Cardiomyocytes, and Cardiac Fibroblasts Causes Cardiac and Vascular Dysfunction.
Del Monte-Monge A, Ruiz-Polo de Lara Í, Gonzalo P, Espinós-Estévez C, González-Amor M, de la Fuente-Pérez M, Andrés-Manzano MJ, Fanjul V, Gimeno JR, Barriales-Villa R, Dorado B, Andrés V. Del Monte-Monge A, et al. Among authors: dorado b. Int J Mol Sci. 2023 Jul 6;24(13):11172. doi: 10.3390/ijms241311172. Int J Mol Sci. 2023. PMID: 37446344 Free PMC article.
Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome.
Dorado B, Pløen GG, Barettino A, Macías A, Gonzalo P, Andrés-Manzano MJ, González-Gómez C, Galán-Arriola C, Alfonso JM, Lobo M, López-Martín GJ, Molina A, Sánchez-Sánchez R, Gadea J, Sánchez-González J, Liu Y, Callesen H, Filgueiras-Rama D, Ibáñez B, Sørensen CB, Andrés V. Dorado B, et al. Cell Discov. 2019 Mar 19;5:16. doi: 10.1038/s41421-019-0084-z. eCollection 2019. Cell Discov. 2019. PMID: 30911407 Free PMC article.
37 results