Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 2
2005 3
2006 4
2007 3
2008 7
2009 8
2010 14
2011 20
2012 20
2013 36
2014 37
2015 49
2016 53
2017 44
2018 43
2019 68
2020 68
2021 65
2022 63
2023 59
2024 19

Text availability

Article attribute

Article type

Publication date

Search Results

617 results

Results by year

Filters applied: . Clear all
Page 1
Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells.
Lin H, Cheng K, Kubota H, Lan Y, Riedel SS, Kakiuchi K, Sasaki K, Bernt KM, Bartolomei MS, Luo M, Wang PJ. Lin H, et al. Genes Dev. 2022 Jun 1;36(11-12):752-763. doi: 10.1101/gad.349550.122. Epub 2022 Jun 23. Genes Dev. 2022. PMID: 35738678 Free PMC article.
However, the underlying mechanisms remain enigmatic. Here, we show that DOT1L, the sole H3K79 methyltransferase, is required for spermatogonial stem cell self-renewal. ...Inhibition of DOT1L reduces the stem cell activity after transplantation. DOT1L promotes …
However, the underlying mechanisms remain enigmatic. Here, we show that DOT1L, the sole H3K79 methyltransferase, is required for sper …
DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer.
Kurani H, Razavipour SF, Harikumar KB, Dunworth M, Ewald AJ, Nasir A, Pearson G, Van Booven D, Zhou Z, Azzam D, Wahlestedt C, Slingerland J. Kurani H, et al. Clin Cancer Res. 2022 May 2;28(9):1948-1965. doi: 10.1158/1078-0432.CCR-21-1299. Clin Cancer Res. 2022. PMID: 35135840 Free PMC article.
Antitumor activity was also tested in TNBC PDX and PDX-derived organoids. RESULTS: ALDH1+ TNBC cells exhibit higher DOT1L and H3K79me2 than ALDH1-. DOT1L maintains MYC expression and self-renewal in ALDH1+ cells. ...EPZ-5676 significantly reduced growth in vivo of o …
Antitumor activity was also tested in TNBC PDX and PDX-derived organoids. RESULTS: ALDH1+ TNBC cells exhibit higher DOT1L and H3K79me …
The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-kappaB pathway.
Farina FM, Serio S, Hall IF, Zani S, Cassanmagnago GA, Climent M, Civilini E, Condorelli G, Quintavalle M, Elia L. Farina FM, et al. Eur Heart J. 2022 Nov 14;43(43):4562-4576. doi: 10.1093/eurheartj/ehac097. Eur Heart J. 2022. PMID: 35292818
CONCLUSION: DOT1L plays a key role in the epigenetic control of VSMC gene expression, leading to atherosclerosis development. Results identify DOT1L as a potential therapeutic target for vascular diseases....
CONCLUSION: DOT1L plays a key role in the epigenetic control of VSMC gene expression, leading to atherosclerosis development. Results …
The Role of DOT1L in Normal and Malignant Hematopoiesis.
Arnold O, Barbosa K, Deshpande AJ, Zhu N. Arnold O, et al. Front Cell Dev Biol. 2022 May 26;10:917125. doi: 10.3389/fcell.2022.917125. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35712672 Free PMC article. Review.
A notable developmental process reliant on DOT1L function is normal hematopoiesis, as DOT1L knockout leads to impairment in blood lineage formation. ...Recent studies have uncovered methyltransferase-independent functions and a novel mechanism of DOT1L functi …
A notable developmental process reliant on DOT1L function is normal hematopoiesis, as DOT1L knockout leads to impairment in bl …
The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
Lin H, Cossu IG, Leu NA, Deshpande AJ, Bernt KM, Luo M, Wang PJ. Lin H, et al. Development. 2023 May 1;150(9):dev201501. doi: 10.1242/dev.201501. Epub 2023 May 12. Development. 2023. PMID: 37082953
Here, we report that DOT1L regulates male fertility in mouse. DOT1L associates with MLLT10 in testis. ...Loss of either DOT1L or MLLT10 leads to reduced testis weight, decreased sperm count and male subfertility. ...
Here, we report that DOT1L regulates male fertility in mouse. DOT1L associates with MLLT10 in testis. ...Loss of either DOT …
Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells.
Zhao X, Li X, Sun H, Zhao X, Gao T, Shi P, Chen F, Liu L, Lu X. Zhao X, et al. Nucleic Acids Res. 2023 Sep 22;51(17):8970-8986. doi: 10.1093/nar/gkad640. Nucleic Acids Res. 2023. PMID: 37522386 Free PMC article.
In contradiction, Dot1l also participates in silencing gene expression. The target regions and mechanism of Dot1l in repressing transcription remain enigmatic. ...Furthermore, Dot1l is critical for Npm1 to efficiently interact with histone H1 and inhibit ubiq …
In contradiction, Dot1l also participates in silencing gene expression. The target regions and mechanism of Dot1l in repressin …
DOT1L regulates chromatin reorganization and gene expression during sperm differentiation.
Blanco M, El Khattabi L, Gobé C, Crespo M, Coulée M, de la Iglesia A, Ialy-Radio C, Lapoujade C, Givelet M, Delessard M, Seller-Corona I, Yamaguchi K, Vernet N, Van Leeuwen F, Lermine A, Okada Y, Daveau R, Oliva R, Fouchet P, Ziyyat A, Pflieger D, Cocquet J. Blanco M, et al. EMBO Rep. 2023 Jun 5;24(6):e56316. doi: 10.15252/embr.202256316. Epub 2023 Apr 26. EMBO Rep. 2023. PMID: 37099396 Free PMC article.
Using a mouse model in which Dot1l is knocked-out (KO) in postnatal male germ cells, we found that Dot1l-KO sperm chromatin is less compact and has an abnormal content, characterized by the presence of transition proteins, immature protamine 2 forms and a higher lev …
Using a mouse model in which Dot1l is knocked-out (KO) in postnatal male germ cells, we found that Dot1l-KO sperm chromatin is …
DOT1L and H3K79 Methylation in Transcription and Genomic Stability.
Wood K, Tellier M, Murphy S. Wood K, et al. Biomolecules. 2018 Feb 27;8(1):11. doi: 10.3390/biom8010011. Biomolecules. 2018. PMID: 29495487 Free PMC article. Review.
H3K79 methylation is implicated in several processes, including transcription elongation by RNA polymerase II, the DNA damage response and cell cycle checkpoint activation. DOT1L is also an important drug target for treatment of mixed lineage leukemia (MLL)-rearranged leuk …
H3K79 methylation is implicated in several processes, including transcription elongation by RNA polymerase II, the DNA damage response and c …
A novel role of DOT1L in kidney diseases.
Wei W, Zhao Y, Chai Y, Shou S, Jin H. Wei W, et al. Mol Biol Rep. 2023 Jun;50(6):5415-5423. doi: 10.1007/s11033-023-08415-3. Epub 2023 Apr 22. Mol Biol Rep. 2023. PMID: 37085741 Review.
BACKGROUND: We systematically summarized the structure and biological function of DOT1L in detail, and further discussed the role of DOT1L in kidney diseases through different mechanisms. METHODS AND RESULTS: We first described the role of DOT1L in various ki …
BACKGROUND: We systematically summarized the structure and biological function of DOT1L in detail, and further discussed the role of …
Nucleoside and Non-Nucleoside DOT1L Inhibitors: Dawn of MLLrearranged Leukemia.
Cao M, Li T, Chen Y, Zhai X. Cao M, et al. Mini Rev Med Chem. 2021;21(11):1337-1350. doi: 10.2174/1389557521666210111144357. Mini Rev Med Chem. 2021. PMID: 33430727 Review.
Herein, the underlying role of disruptor of telomeric silencing 1-like (DOT1L) as a therapeutic target for mixed-lineage leukemia (MLL)-rearranged is comprehensively clarified. ...Accordingly, blockading of DOT1L has been recognized as an effective approach for canc …
Herein, the underlying role of disruptor of telomeric silencing 1-like (DOT1L) as a therapeutic target for mixed-lineage leukemia (ML …
617 results