Downing JR - Search Results

1

MN1 overexpression is an important step in the development of inv(16) AML.

Carella C, Bonten J, Sirma S, Kranenburg TA, Terranova S, Klein-Geltink R, Shurtleff S, Downing JR, Zwarthoff EC, Liu PP, Grosveld GC. Carella C, et al. Among authors: downing jr. Leukemia. 2007 Aug;21(8):1679-90. doi: 10.1038/sj.leu.2404778. Epub 2007 May 24. Leukemia. 2007. PMID: 17525718

2

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

Shurtleff SA, Buijs A, Behm FG, Rubnitz JE, Raimondi SC, Hancock ML, Chan GC, Pui CH, Grosveld G, Downing JR. Shurtleff SA, et al. Among authors: downing jr. Leukemia. 1995 Dec;9(12):1985-9. Leukemia. 1995. PMID: 8609706

3

The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription.

Hiebert SW, Sun W, Davis JN, Golub T, Shurtleff S, Buijs A, Downing JR, Grosveld G, Roussell MF, Gilliland DG, Lenny N, Meyers S. Hiebert SW, et al. Among authors: downing jr. Mol Cell Biol. 1996 Apr;16(4):1349-55. doi: 10.1128/MCB.16.4.1349. Mol Cell Biol. 1996. PMID: 8657108 Free PMC article.

4

Molecular analysis of the PML/RAR alpha chimeric gene in pediatric acute promyelocytic leukemia.

Kane JR, Head DR, Balazs L, Hulshof MG, Motroni TA, Raimondi SC, Carroll AJ, Behm FG, Krance RA, Shurtleff SA, Downing JR. Kane JR, et al. Among authors: downing jr. Leukemia. 1996 Aug;10(8):1296-302. Leukemia. 1996. PMID: 8709634

5

Genetic studies of childhood acute lymphoblastic leukemia with emphasis on p16, MLL, and ETV6 gene abnormalities: results of St Jude Total Therapy Study XII.

Rubnitz JE, Behm FG, Pui CH, Evans WE, Relling MV, Raimondi SC, Harrison PL, Sandlund JT, Ribeiro RC, Grosveld G, Downing JR. Rubnitz JE, et al. Among authors: downing jr. Leukemia. 1997 Aug;11(8):1201-6. doi: 10.1038/sj.leu.2400779. Leukemia. 1997. PMID: 9264370

6

A multiplex RT-PCR assay for the detection of chimeric transcripts encoded by the risk-stratifying translocations of pediatric acute lymphoblastic leukemia.

Scurto P, Hsu Rocha M, Kane JR, Williams WK, Haney DM, Conn WP, Shurtleff SA, Downing JR. Scurto P, et al. Among authors: downing jr. Leukemia. 1998 Dec;12(12):1994-2005. doi: 10.1038/sj.leu.2401224. Leukemia. 1998. PMID: 9844930

7

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias.

Mullighan CG, Kennedy A, Zhou X, Radtke I, Phillips LA, Shurtleff SA, Downing JR. Mullighan CG, et al. Among authors: downing jr. Leukemia. 2007 Sep;21(9):2000-9. doi: 10.1038/sj.leu.2404808. Epub 2007 Jun 28. Leukemia. 2007. PMID: 17597811

8

IDH1 and IDH2 mutations in pediatric acute leukemia.

Andersson AK, Miller DW, Lynch JA, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, Schulman BA, Downing JR. Andersson AK, et al. Among authors: downing jr. Leukemia. 2011 Oct;25(10):1570-7. doi: 10.1038/leu.2011.133. Epub 2011 Jun 7. Leukemia. 2011. PMID: 21647154 Free PMC article.

9

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis.

Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. Okuda T, et al. Among authors: downing jr. Cell. 1996 Jan 26;84(2):321-30. doi: 10.1016/s0092-8674(00)80986-1. Cell. 1996. PMID: 8565077 Free article.

10

Molecular analysis of t(11;19) breakpoints in childhood acute leukemias.

Rubnitz JE, Behm FG, Curcio-Brint AM, Pinheiro RP, Carroll AJ, Raimondi SC, Shurtleff SA, Downing JR. Rubnitz JE, et al. Among authors: downing jr. Blood. 1996 Jun 1;87(11):4804-8. Blood. 1996. PMID: 8639852 Free article.

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