Downing SM - Search Results

1

Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration.

Kwak YD, Shaw TI, Downing SM, Tewari A, Jin H, Li Y, Dumitrache LC, Katyal S, Khodakhah K, Russell HR, McKinnon PJ. Kwak YD, et al. Among authors: downing sm. Sci Adv. 2021 Dec 17;7(51):eabg6363. doi: 10.1126/sciadv.abg6363. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910524 Free article.

2

Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.

Lee Y, Katyal S, Downing SM, Zhao J, Russell HR, McKinnon PJ. Lee Y, et al. Among authors: downing sm. Nat Neurosci. 2012 Jun;15(6):819-26. doi: 10.1038/nn.3097. Nat Neurosci. 2012. PMID: 22522401 Free PMC article.

3

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.

Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ. Katyal S, et al. Among authors: downing sm. Nat Neurosci. 2014 Jun;17(6):813-21. doi: 10.1038/nn.3715. Epub 2014 May 4. Nat Neurosci. 2014. PMID: 24793032 Free PMC article.

4

DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

Enriquez-Rios V, Dumitrache LC, Downing SM, Li Y, Brown EJ, Russell HR, McKinnon PJ. Enriquez-Rios V, et al. Among authors: downing sm. J Neurosci. 2017 Jan 25;37(4):893-905. doi: 10.1523/JNEUROSCI.4213-15.2016. J Neurosci. 2017. PMID: 28123024 Free PMC article.

5

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.

Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A. Ratnaparkhe M, et al. Among authors: downing sm. Nat Commun. 2018 Nov 12;9(1):4760. doi: 10.1038/s41467-018-06925-4. Nat Commun. 2018. PMID: 30420702 Free PMC article.

6

Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.

Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ. Dumitrache LC, et al. Among authors: downing sm. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294. doi: 10.1073/pnas.1809682115. Epub 2018 Dec 11. Proc Natl Acad Sci U S A. 2018. PMID: 30538199 Free PMC article.

7

Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair.

Aditi, Downing SM, Schreiner PA, Kwak YD, Li Y, Shaw TI, Russell HR, McKinnon PJ. Aditi, et al. Among authors: downing sm. Neuron. 2021 Dec 15;109(24):3962-3979.e6. doi: 10.1016/j.neuron.2021.09.040. Epub 2021 Oct 15. Neuron. 2021. PMID: 34655526 Free PMC article.

8

Simultaneous Nbs1 and p53 inactivation in neural progenitors triggers high-grade gliomas.

Reuss DE, Downing SM, Camacho CV, Wang YD, Piro RM, Herold-Mende C, Wang ZQ, Hofmann TG, Sahm F, von Deimling A, McKinnon PJ, Frappart PO. Reuss DE, et al. Among authors: downing sm. Neuropathol Appl Neurobiol. 2023 Aug;49(4):e12915. doi: 10.1111/nan.12915. Neuropathol Appl Neurobiol. 2023. PMID: 37296499

9

Haploinsufficiency of the lysosomal sialidase NEU1 results in a model of pleomorphic rhabdomyosarcoma in mice.

Machado ER, van de Vlekkert D, Sheppard HS, Perry S, Downing SM, Laxton J, Ashmun R, Finkelstein DB, Neale GA, Hu H, Harwood FC, Koo SC, Grosveld GC, d'Azzo A. Machado ER, et al. Among authors: downing sm. Commun Biol. 2022 Sep 20;5(1):992. doi: 10.1038/s42003-022-03968-8. Commun Biol. 2022. PMID: 36127469 Free PMC article.

10

Applying the Bookmark method to medical education: standard setting for an aseptic technique station.

Lypson ML, Downing SM, Gruppen LD, Yudkowsky R. Lypson ML, et al. Among authors: downing sm. Med Teach. 2013 Jul;35(7):581-5. doi: 10.3109/0142159X.2013.778395. Epub 2013 Apr 18. Med Teach. 2013. PMID: 23597240

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