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Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J, Rosenthal PJ, McKerrow JH, Guy RK. Fujii N, et al. Among authors: doyle p. Bioorg Med Chem Lett. 2005 Jan 3;15(1):121-3. doi: 10.1016/j.bmcl.2004.10.023. Bioorg Med Chem Lett. 2005. PMID: 15582423
The Trypanosoma cruzi protease cruzain mediates immune evasion.
Doyle PS, Zhou YM, Hsieh I, Greenbaum DC, McKerrow JH, Engel JC. Doyle PS, et al. PLoS Pathog. 2011 Sep;7(9):e1002139. doi: 10.1371/journal.ppat.1002139. Epub 2011 Sep 1. PLoS Pathog. 2011. PMID: 21909255 Free PMC article.
Development of protease inhibitors for protozoan infections.
McKerrow JH, Rosenthal PJ, Swenerton R, Doyle P. McKerrow JH, et al. Among authors: doyle p. Curr Opin Infect Dis. 2008 Dec;21(6):668-72. doi: 10.1097/QCO.0b013e328315cca9. Curr Opin Infect Dis. 2008. PMID: 18978536 Free PMC article. Review.
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Caffrey CR, Steverding D, Swenerton RK, Kelly B, Walshe D, Debnath A, Zhou YM, Doyle PS, Fafarman AT, Zorn JA, Land KM, Beauchene J, Schreiber K, Moll H, Ponte-Sucre A, Schirmeister T, Saravanamuthu A, Fairlamb AH, Cohen FE, McKerrow JH, Weisman JL, May BC. Caffrey CR, et al. Antimicrob Agents Chemother. 2007 Jun;51(6):2164-72. doi: 10.1128/AAC.01418-06. Epub 2007 Mar 19. Antimicrob Agents Chemother. 2007. PMID: 17371810 Free PMC article.
980 results