Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2011 2
2016 1
2018 1
2019 1
2020 2
2022 2
2023 1
2024 3

Text availability

Article attribute

Article type

Publication date

Search Results

14 results

Results by year

Filters applied: . Clear all
Page 1
The testis-specifically expressed Dpep3 is not essential for male fertility in mice.
Xie Y, Khan R, Wahab F, Hussain HMJ, Ali A, Ma H, Jiang H, Xu J, Zaman Q, Khan M, Jiang X, Shi Q. Xie Y, et al. Gene. 2019 Aug 30;711:143925. doi: 10.1016/j.gene.2019.06.015. Epub 2019 Jun 15. Gene. 2019. PMID: 31212048
Its mRNA was exclusively detected in testicular tissue and expressed in testes from 7 days postpartum. To further explore its role in male fertility, we generated Dpep3 knockout mice (Dpep3(-/-)) using the CRISPR/Cas9 technology and found that the male Dpep3( …
Its mRNA was exclusively detected in testicular tissue and expressed in testes from 7 days postpartum. To further explore its role in male f …
Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.
Hayashi K, Longenecker KL, Koenig P, Prashar A, Hampl J, Stoll V, Vivona S. Hayashi K, et al. J Struct Biol. 2020 Jul 1;211(1):107512. doi: 10.1016/j.jsb.2020.107512. Epub 2020 Apr 20. J Struct Biol. 2020. PMID: 32325220 Free article.
The structure of DPEP3/SC-003 Fab complex reveals an eighteen-residue epitope across the DPEP3 dimerization interface distinct from the enzymatic active site. ...Hence DPEP3, unlike DPEP1 and DPEP2, may require an activating co-factor in vivo or may remain an …
The structure of DPEP3/SC-003 Fab complex reveals an eighteen-residue epitope across the DPEP3 dimerization interface distinct …
Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies.
Schiza C, Korbakis D, Panteleli E, Jarvi K, Drabovich AP, Diamandis EP. Schiza C, et al. Mol Cell Proteomics. 2018 Dec;17(12):2480-2495. doi: 10.1074/mcp.RA118.000749. Epub 2018 Aug 10. Mol Cell Proteomics. 2018. PMID: 30097533 Free PMC article.
Combinations of antibodies recognizing different epitopes of TEX101 and DPEP3 facilitated development of a simple immunoassay to screen for disruptors of TEX101-DPEP3 complex. As a proof-of-a-concept, we demonstrated that anti-TEX101 antibody T4 disrupted the native …
Combinations of antibodies recognizing different epitopes of TEX101 and DPEP3 facilitated development of a simple immunoassay to scre …
Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer.
Hikmet F, Rassy M, Backman M, Méar L, Mattsson JSM, Djureinovic D, Botling J, Brunnström H, Micke P, Lindskog C. Hikmet F, et al. Mol Oncol. 2023 Dec;17(12):2603-2617. doi: 10.1002/1878-0261.13474. Epub 2023 Jun 27. Mol Oncol. 2023. PMID: 37341056 Free PMC article.
We aimed to characterize CTA expression in non-small cell lung cancer (NSCLC) in the context of the immune microenvironment. Of 90 CTAs validated by RNA sequencing, eight CTAs (DPEP3, EZHIP, MAGEA4, MAGEB2, MAGEC2, PAGE1, PRAME, and TKTL1) were selected for immunohistochem …
We aimed to characterize CTA expression in non-small cell lung cancer (NSCLC) in the context of the immune microenvironment. Of 90 CTAs vali …
Comprehensive bioinformatics analysis of co-expressed genes of post-traumatic stress disorder and major depressive disorder.
Zhang H, Luo P, Jiang X. Zhang H, et al. J Affect Disord. 2024 Mar 15;349:541-551. doi: 10.1016/j.jad.2024.01.098. Epub 2024 Jan 11. J Affect Disord. 2024. PMID: 38218255
The study findings reveal decreased expression levels of DPEP3, GNAQ, and PACDIN2 in PTSD samples, accompanied by an increased expression of ICAM2. In MDD samples, the expression of DPEP3 and ICAM2 is reduced, whereas GNAQ and PACDIN2 show an increase in expression. …
The study findings reveal decreased expression levels of DPEP3, GNAQ, and PACDIN2 in PTSD samples, accompanied by an increased expres …
Effects of varicocele and microsurgical varicocelectomy on the metabolites in semen.
Zhang X, Deng C, Liu W, Liu H, Zhou Y, Li Q, Zheng H, Wang Q, Jiang M, Pang T, Ma C, Huang C, Zhao Q, Tang Y. Zhang X, et al. Sci Rep. 2022 Mar 25;12(1):5179. doi: 10.1038/s41598-022-08954-y. Sci Rep. 2022. PMID: 35338186 Free PMC article.
Interestingly, the levels of these three dipeptides decreased after microsurgical varicocelectomy coincident with an improvement in semen quality. Western blotting confirmed the downregulation of DPEP3 (dipeptidase 3) in the varicocele group and the upregulation of DPEP …
Interestingly, the levels of these three dipeptides decreased after microsurgical varicocelectomy coincident with an improvement in semen qu …
Tamrintamab pamozirine (SC-003) in patients with platinum-resistant/refractory ovarian cancer: Findings of a phase 1 study.
Hamilton E, O'Malley DM, O'Cearbhaill R, Cristea M, Fleming GF, Tariq B, Fong A, French D, Rossi M, Brickman D, Moore K. Hamilton E, et al. Gynecol Oncol. 2020 Sep;158(3):640-645. doi: 10.1016/j.ygyno.2020.05.038. Epub 2020 Jun 6. Gynecol Oncol. 2020. PMID: 32513564 Free PMC article. Clinical Trial.
SC-003 is a pyrrolobenzodiazepine-based antibody-drug conjugate targeting dipeptidase 3 (DPEP3), a membrane-bound dipeptidase associated with tumor-initiating cells in patient-derived EOC xenograft models. ...Post-hoc examination of antitumor activity suggested a higher re …
SC-003 is a pyrrolobenzodiazepine-based antibody-drug conjugate targeting dipeptidase 3 (DPEP3), a membrane-bound dipeptidase associa …
Lycium barbarum polysaccharide modulates gut microbiota to alleviate rheumatoid arthritis in a rat model.
Lai W, Wang C, Lai R, Peng X, Luo J. Lai W, et al. NPJ Sci Food. 2022 Jul 21;6(1):34. doi: 10.1038/s41538-022-00149-z. NPJ Sci Food. 2022. PMID: 35864275 Free PMC article.
The mRNA contents of several colonic epithelial genes including Dpep3, Gstm6, Slc27a2, Col11a2, Sycp2, SNORA22, Tnni1, Gpnmb, Mypn and Acsl6, which are potentially associated to RA, were down-regulated due to the DNA hypermethylation, possibly caused by the elevating conte …
The mRNA contents of several colonic epithelial genes including Dpep3, Gstm6, Slc27a2, Col11a2, Sycp2, SNORA22, Tnni1, Gpnmb, Mypn an …
Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis.
Yoshitake H, Yanagida M, Maruyama M, Takamori K, Hasegawa A, Araki Y. Yoshitake H, et al. J Reprod Immunol. 2011 Aug;90(2):202-13. doi: 10.1016/j.jri.2011.04.010. Epub 2011 Jul 2. J Reprod Immunol. 2011. PMID: 21724266
Expression of DPEP3 protein was observed in the testicular germ cells, but not in the Sertoli or interstitial cells, or in any other major organs. Although Western blot analysis of testicular proteins separated by two-dimensional SDS-PAGE failed to demonstrate binding of T …
Expression of DPEP3 protein was observed in the testicular germ cells, but not in the Sertoli or interstitial cells, or in any other …
Proteomic biomarkers in seminal plasma as predictors of reproductive potential in azoospermic men.
Fietz D, Sgaier R, O'Donnell L, Stanton PG, Dagley LF, Webb AI, Schuppe HC, Diemer T, Pilatz A. Fietz D, et al. Front Endocrinol (Lausanne). 2024 Apr 9;15:1327800. doi: 10.3389/fendo.2024.1327800. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38654926 Free PMC article.
Analysis of tissue and cell expression suggested that the testis-specific proteins LDHC, PGK2, DPEP3, and germ-cell enriched heat-shock proteins HSPA2 and HSPA4L are promising biomarkers of spermatogenic function. ...
Analysis of tissue and cell expression suggested that the testis-specific proteins LDHC, PGK2, DPEP3, and germ-cell enriched heat-sho …
14 results