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1993 2
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2000 1
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2013 3
2014 1
2015 4
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The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression.
Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Shiekhattar R, Morey L, Bilbao D, Nimer SD. Mas G, et al. J Clin Invest. 2023 Jul 3;133(13):e158419. doi: 10.1172/JCI158419. J Clin Invest. 2023. PMID: 37200093 Free PMC article.
If unresolved, this process leads to sustained inflammation, which can cause life-threatening diseases and cancer. Here, we identify a role of double PHD fingers 2 (DPF2) in modulating inflammation. DPF2 is a defining subunit of the hematopoiesis-specific BAF (SWI/S …
If unresolved, this process leads to sustained inflammation, which can cause life-threatening diseases and cancer. Here, we identify a role …
Coffin-Siris Syndrome.
Schrier Vergano S, Santen G, Wieczorek D, Wollnik B, Matsumoto N, Deardorff MA. Schrier Vergano S, et al. 2013 Apr 4 [updated 2021 Aug 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2013 Apr 4 [updated 2021 Aug 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 23556151 Free Books & Documents. Review.
DPF2 regulates OCT4 protein level and nuclear distribution.
Liu C, Zhang D, Shen Y, Tao X, Liu L, Zhong Y, Fang S. Liu C, et al. Biochim Biophys Acta. 2015 Dec;1853(12):3279-93. doi: 10.1016/j.bbamcr.2015.09.029. Epub 2015 Sep 28. Biochim Biophys Acta. 2015. PMID: 26417682 Free article.
Moreover, overexpression of both DPF2 and OCT4 in 293 cells proved the DPF2-OCT4 interaction. DPF2 but not PHD2 mutant DPF2 enhanced ubiquitination and degradation of OCT4 in 293 cells co-expressed DPF2 and OCT4. Both wild type DPF2 and P …
Moreover, overexpression of both DPF2 and OCT4 in 293 cells proved the DPF2-OCT4 interaction. DPF2 but not PHD2 mutant …
Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.
Huber FM, Greenblatt SM, Davenport AM, Martinez C, Xu Y, Vu LP, Nimer SD, Hoelz A. Huber FM, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6016-6021. doi: 10.1073/pnas.1700328114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533407 Free PMC article.
Here, we present the crystal structure of the tandem plant homeodomain finger domain of human DPF2 at 1.6-A resolution. We show that DPF2 interacts with the acetylated tails of both histones 3 and 4 via bipartite binding pockets on the DPF2 surface. ...Our fi …
Here, we present the crystal structure of the tandem plant homeodomain finger domain of human DPF2 at 1.6-A resolution. We show that …
Genotype-Phenotype Correlations in 208 Individuals with Coffin-Siris Syndrome.
Vasko A, Drivas TG, Schrier Vergano SA. Vasko A, et al. Genes (Basel). 2021 Jun 19;12(6):937. doi: 10.3390/genes12060937. Genes (Basel). 2021. PMID: 34205270 Free PMC article.
Genes in the BRG1(BRM)-associated factors (BAF, Brahma associated factor) complex have been shown to be causative, including ARID1A, ARID1B, ARID2, DPF2, SMARCA4, SMARCB1, SMARCC2, SMARCE1, SOX11, and SOX4. In order to describe more robust genotype-phenotype correlations, …
Genes in the BRG1(BRM)-associated factors (BAF, Brahma associated factor) complex have been shown to be causative, including ARID1A, ARID1B, …
DPF2-related Coffin-Siris syndrome type 7 in two generations.
Kolokotronis K, Suter AA, Ivanovski I, Frey T, Bahr A, Rauch A, Steindl K. Kolokotronis K, et al. Eur J Med Genet. 2024 Apr 30;69:104945. doi: 10.1016/j.ejmg.2024.104945. Online ahead of print. Eur J Med Genet. 2024. PMID: 38697389 Free article.
All reported patients carried de novo variants with presumed dominant negative effect, which localized in the PHD1/PHD2 domains of DPF2. Here we report on the first familial case of Coffin-Siris syndrome type 7. ...To our knowledge this is the first report of an inherited …
All reported patients carried de novo variants with presumed dominant negative effect, which localized in the PHD1/PHD2 domains of DPF2 …
The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation.
Zhang W, Chronis C, Chen X, Zhang H, Spalinskas R, Pardo M, Chen L, Wu G, Zhu Z, Yu Y, Yu L, Choudhary J, Nichols J, Parast MM, Greber B, Sahlén P, Plath K. Zhang W, et al. Cell Stem Cell. 2019 Jan 3;24(1):138-152.e8. doi: 10.1016/j.stem.2018.12.001. Cell Stem Cell. 2019. PMID: 30609396 Free PMC article.
BAF complexes are composed of different subunits with varying functional and developmental roles, although many subunits have not been examined in depth. Here we show that the Baf45 subunit Dpf2 maintains pluripotency and ESC differentiation potential. Dpf2 co-occup …
BAF complexes are composed of different subunits with varying functional and developmental roles, although many subunits have not been exami …
Mutations in the BAF-Complex Subunit DPF2 Are Associated with Coffin-Siris Syndrome.
Vasileiou G, Vergarajauregui S, Endele S, Popp B, Büttner C, Ekici AB, Gerard M, Bramswig NC, Albrecht B, Clayton-Smith J, Morton J, Tomkins S, Low K, Weber A, Wenzel M, Altmüller J, Li Y, Wollnik B, Hoganson G, Plona MR, Cho MT; Deciphering Developmental Disorders Study; Thiel CT, Lüdecke HJ, Strom TM, Calpena E, Wilkie AOM, Wieczorek D, Engel FB, Reis A. Vasileiou G, et al. Am J Hum Genet. 2018 Mar 1;102(3):468-479. doi: 10.1016/j.ajhg.2018.01.014. Epub 2018 Feb 8. Am J Hum Genet. 2018. PMID: 29429572 Free PMC article.
Pull-down assays of recombinant proteins and histone peptides revealed that a subset of the identified missense variants abolish or impaire DPF2 binding to unmodified and modified H3 histone tails. These results suggest an impairment of PHD finger structural integrity and …
Pull-down assays of recombinant proteins and histone peptides revealed that a subset of the identified missense variants abolish or impaire …
Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of stem cell maintenance and neuronal differentiation.
Nazim M, Lin CH, Feng AC, Xiao W, Yeom KH, Li M, Daly AE, Tan X, Vu H, Ernst J, Carey MF, Smale ST, Black DL. Nazim M, et al. Cell Stem Cell. 2024 May 2;31(5):754-771.e6. doi: 10.1016/j.stem.2024.04.001. Cell Stem Cell. 2024. PMID: 38701759 Free article.
Dpf2 exon 7 splicing is inhibited by PTBP1 to produce the DPF2-S isoform early in development. ...DPF2-S sites exhibited enhancer modifications, while DPF2-L sites showed promoter modifications. ...
Dpf2 exon 7 splicing is inhibited by PTBP1 to produce the DPF2-S isoform early in development. ...DPF2-S sites exhibite …
56 results