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Huntingtin is required for normal hematopoiesis.
Metzler M, Helgason CD, Dragatsis I, Zhang T, Gan L, Pineault N, Zeitlin SO, Humphries RK, Hayden MR. Metzler M, et al. Among authors: dragatsis i. Hum Mol Genet. 2000 Feb 12;9(3):387-94. doi: 10.1093/hmg/9.3.387. Hum Mol Genet. 2000. PMID: 10655548
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT. Trushina E, et al. Among authors: dragatsis i. Mol Cell Biol. 2004 Sep;24(18):8195-209. doi: 10.1128/MCB.24.18.8195-8209.2004. Mol Cell Biol. 2004. PMID: 15340079 Free PMC article.
Huntingtin inhibits caspase-3 activation.
Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM. Zhang Y, et al. Among authors: dragatsis i. EMBO J. 2006 Dec 13;25(24):5896-906. doi: 10.1038/sj.emboj.7601445. Epub 2006 Nov 23. EMBO J. 2006. PMID: 17124493 Free PMC article.
61 results