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Conformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic α-helical peptides.
Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, McIntyre CA, Yam WC, Siu G, Atkinson RA, Lam JK, Bansal SS, Drake AF, Mitchell GH, Mason AJ. Vermeer LS, et al. Among authors: drake af. J Biol Chem. 2012 Oct 5;287(41):34120-33. doi: 10.1074/jbc.M112.359067. Epub 2012 Aug 6. J Biol Chem. 2012. PMID: 22869378 Free PMC article.
A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy.
Manzo G, Hind CK, Ferguson PM, Amison RT, Hodgson-Casson AC, Ciazynska KA, Weller BJ, Clarke M, Lam C, Man RCH, Shaughnessy BGO, Clifford M, Bui TT, Drake AF, Atkinson RA, Lam JKW, Pitchford SC, Page CP, Phoenix DA, Lorenz CD, Sutton JM, Mason AJ. Manzo G, et al. Among authors: drake af. Commun Biol. 2020 Nov 27;3(1):697. doi: 10.1038/s42003-020-01420-3. Commun Biol. 2020. PMID: 33247193 Free PMC article.
Manipulating the pH response of 2,3-diaminopropionic acid rich peptides to mediate highly effective gene silencing with low-toxicity.
Abbate V, Liang W, Patel J, Lan Y, Capriotti L, Iacobucci V, Bui TT, Chaudhuri P, Kudsiova L, Vermeer LS, Chan PF, Kong X, Drake AF, Lam JK, Bansal SS, Mason AJ. Abbate V, et al. Among authors: drake af. J Control Release. 2013 Dec 28;172(3):929-38. doi: 10.1016/j.jconrel.2013.09.033. Epub 2013 Oct 18. J Control Release. 2013. PMID: 24144917 Free PMC article.
205 results