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DRG2 Depletion Promotes Endothelial Cell Senescence and Vascular Endothelial Dysfunction.
Le AN, Park SS, Le MX, Lee UH, Ko BK, Lim HR, Yu R, Choi SH, Lee BJ, Ham SY, Ha CM, Park JW. Le AN, et al. Int J Mol Sci. 2022 Mar 6;23(5):2877. doi: 10.3390/ijms23052877. Int J Mol Sci. 2022. PMID: 35270019 Free PMC article.
Here, we demonstrated that deficiency of developmentally regulated GTP-binding protein 2 (DRG2) induces senescence and dysfunction of endothelial cells. DRG2 knockout (KO) mice displayed reduced cerebral blood flow in the brain and lung blood vessel density. ...D …
Here, we demonstrated that deficiency of developmentally regulated GTP-binding protein 2 (DRG2) induces senescence and dysfunction of …
DRG2 Accelerates Senescence via Negative Regulation of SIRT1 in Human Diploid Fibroblasts.
Li BS, Jin AL, Zhou Z, Seo JH, Choi BM. Li BS, et al. Oxid Med Cell Longev. 2021 Nov 3;2021:7301373. doi: 10.1155/2021/7301373. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34777693 Free PMC article.
However, the effect of DRG2 in aging remains unclear. In this study, we found that endogenous DRG2 protein expression is upregulated in oxidative stress-induced premature senescence models and tissues of aged mice. ...Additionally, DRG2 knockdown significantl …
However, the effect of DRG2 in aging remains unclear. In this study, we found that endogenous DRG2 protein expression is upreg …
DRG2 supports the growth of primary tumors and metastases of melanoma by enhancing VEGF-A expression.
Yoon NA, Jung SJ, Choi SH, Ryu JH, Mani M, Lee UH, Vo MT, Jeon DY, Chung SW, Ju Lee B, Koh YW, Park SE, Shin YJ, Kang SS, Cho WJ, Cha HJ, Park JW. Yoon NA, et al. FEBS J. 2020 May;287(10):2070-2086. doi: 10.1111/febs.15125. Epub 2019 Dec 1. FEBS J. 2020. PMID: 31693298 Free article.
DRG2 expression was significantly increased in MM compared with primary melanoma (PM) and dysplastic nevi. ...In experimental mice, DRG2 depletion inhibited the growth of PM and lung metastases and increased survival. ...
DRG2 expression was significantly increased in MM compared with primary melanoma (PM) and dysplastic nevi. ...In experimental mice, …
DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection.
Lee UH, Park SJ, Ju SA, Lee SC, Kim BS, Ahn B, Yi J, Park J, Won YW, Han IS, Lee BJ, Cho WJ, Park JW. Lee UH, et al. Clin Immunol. 2023 Dec;257:109819. doi: 10.1016/j.clim.2023.109819. Epub 2023 Nov 1. Clin Immunol. 2023. PMID: 37918467
Both whole-body DRG2 knockout (KO) mice and macrophage-specific DRG2 KO mice had low levels of IL-6 during early infection and increased susceptibility to L. monocytogenes infection. ...Our findings reveal that DRG2 in macrophages is critical for the initial …
Both whole-body DRG2 knockout (KO) mice and macrophage-specific DRG2 KO mice had low levels of IL-6 during early infection and …
DRG2 knockdown induces Golgi fragmentation via GSK3beta phosphorylation and microtubule stabilization.
Mani M, Thao DT, Kim BC, Lee UH, Kim DJ, Jang SH, Back SH, Lee BJ, Cho WJ, Han IS, Park JW. Mani M, et al. Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1463-1474. doi: 10.1016/j.bbamcr.2019.06.003. Epub 2019 Jun 11. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 31199931 Free article.
In this study, experiments were performed on developmentally regulated GTP-binding protein 2 (DRG2)-stably knockdown HeLa cells to determine whether knockdown of DRG2 in HeLa cells treated with epidermal growth factor (EGF) affects microtubule dynamics, perinuclear …
In this study, experiments were performed on developmentally regulated GTP-binding protein 2 (DRG2)-stably knockdown HeLa cells to de …
DRG2 Deficiency Causes Impaired Microtubule Dynamics in HeLa Cells.
Dang T, Jang SH, Back SH, Park JW, Han IS. Dang T, et al. Mol Cells. 2018 Dec 31;41(12):1045-1051. doi: 10.14348/molcells.2018.0129. Epub 2018 Nov 14. Mol Cells. 2018. PMID: 30453731 Free PMC article.
Here, we demonstrate that DRG2 regulates microtubule dynamics in HeLa cells. Analysis of live imaging of the plus-ends of microtubules with EB1-EGFP showed that DRG2 deficiency (shDRG2) significantly reduced the growth rate of HeLa cells. ...Collectively, these data …
Here, we demonstrate that DRG2 regulates microtubule dynamics in HeLa cells. Analysis of live imaging of the plus-ends of microtubule …
DRG2 Deficient Mice Exhibit Impaired Motor Behaviors with Reduced Striatal Dopamine Release.
Lim HR, Vo MT, Kim DJ, Lee UH, Yoon JH, Kim HJ, Kim J, Kim SR, Lee JY, Yang CH, Kim HY, Choi JS, Kim K, Yang E, Kim H, Lee S, Lee BJ, Kim K, Park JW, Ha CM. Lim HR, et al. Int J Mol Sci. 2019 Dec 20;21(1):60. doi: 10.3390/ijms21010060. Int J Mol Sci. 2019. PMID: 31861806 Free PMC article.
However, the physiological function of DRG2 in the brain remains largely unknown. Here, we demonstrated that knocking out DRG2 impairs the function of dopamine neurons in mice. ...We further demonstrated that dopamine release was significantly diminished in the Str …
However, the physiological function of DRG2 in the brain remains largely unknown. Here, we demonstrated that knocking out DRG2 …
DRG2 Regulates G2/M Progression via the Cyclin B1-Cdk1 Complex.
Jang SH, Kim AR, Park NH, Park JW, Han IS. Jang SH, et al. Mol Cells. 2016 Sep;39(9):699-704. doi: 10.14348/molcells.2016.0149. Epub 2016 Sep 27. Mol Cells. 2016. PMID: 27669826 Free PMC article.
Developmentally regulated GTP-binding protein 2 (DRG2) plays an important role in cell growth. Here we explored the linkage between DRG2 and G2/M phase checkpoint function in cell cycle progression. ...These findings identify a novel role of DRG2 in G2/M prog …
Developmentally regulated GTP-binding protein 2 (DRG2) plays an important role in cell growth. Here we explored the linkage between …
DRG2 is required for surface localization of PD-L1 and the efficacy of anti-PD-1 therapy.
Choi SH, Mani M, Kim J, Cho WJ, Martin TFJ, Kim JH, Chu HS, Jeong WJ, Won YW, Lee BJ, Ahn B, Kim J, Jeon DY, Park JW. Choi SH, et al. Cell Death Discov. 2024 May 27;10(1):260. doi: 10.1038/s41420-024-02027-x. Cell Death Discov. 2024. PMID: 38802348 Free PMC article.
DRG2 depletion enhanced IFN-gamma signaling and increased the PD-L1 level in melanoma cells. However, it inhibited recycling of endosomal PD-L1 and reduced surface PD-L1 levels, which led to defects in interaction with PD-1. Anti-PD-1 did not expand effector-like T cells w …
DRG2 depletion enhanced IFN-gamma signaling and increased the PD-L1 level in melanoma cells. However, it inhibited recycling of endos …
Developmentally regulated GTP-binding protein-2 regulates adipocyte differentiation.
Park BS, Im HL, Yoon NA, Tu TH, Park JW, Kim JG, Lee BJ. Park BS, et al. Biochem Biophys Res Commun. 2021 Nov 12;578:1-6. doi: 10.1016/j.bbrc.2021.08.081. Epub 2021 Aug 29. Biochem Biophys Res Commun. 2021. PMID: 34520979
However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increases in body weight and adiposity in DRG2 transgenic (Tg) mice overexpressing DRG2. Consistent with these results, DRG2 Tg …
However, whether DRG2 regulates adipocyte differentiation and related metabolic control remains elusive. This study revealed increase …
50 results