Drug addiction as a pathology of staged neuroplasticity.
Neuropsychopharmacology. 2008.
PMID: 17805308
Review.
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Drug addiction as a pathology of staged neuroplasticity.
Neuropsychopharmacology. 2008 Jan;33(1):166-80. doi: 10.1038/sj.npp.1301564. Epub 2007 Sep 5.
Neuropsychopharmacology. 2008.
PMID: 17805308
Review.
This growing knowledge has contributed to an expanded understanding of how drugs usurp normal learning circuitry to create the pathology of addiction, as evidenced by involuntary activation of reward circuits in response to drug-associated cues and simultaneo …
This growing knowledge has contributed to an expanded understanding of how drugs usurp normal learning circuitry to create the pathology …
The synaptic pathology of drug addiction.
Adv Exp Med Biol. 2012;970:469-91. doi: 10.1007/978-3-7091-0932-8_21.
Adv Exp Med Biol. 2012.
PMID: 22351069
Review.
A hallmark of drug addiction is the uncontrollable desire to consume drugs at the expense of severe negative consequences. ...Identification of drug-induced neuroplasticity is crucial to understand how molecular and cellular adaptations contribute to t …
A hallmark of drug addiction is the uncontrollable desire to consume drugs at the expense of severe negative consequences. ... …
Striatal morphological and functional alterations induced by prenatal alcohol exposure.
Pharmacol Res. 2019 Apr;142:262-266. doi: 10.1016/j.phrs.2019.02.022. Epub 2019 Feb 23.
Pharmacol Res. 2019.
PMID: 30807864
Free PMC article.
Review.
Prenatal alcohol exposure (PAE) is an insidious yet preventable cause of developmental disability. The prenatal stage is a critical period for brain development with the concurrence of high vulnerability to the acute and prolonged effects of PAE. ...Because this region is …
Prenatal alcohol exposure (PAE) is an insidious yet preventable cause of developmental disability. The prenatal stage is a critical p …
Magnetic nanotherapeutics for dysregulated synaptic plasticity during neuroAIDS and drug abuse.
Mol Brain. 2016 May 23;9(1):57. doi: 10.1186/s13041-016-0236-0.
Mol Brain. 2016.
PMID: 27216740
Free PMC article.
Review.
Neurological illnesses weaken the connections between neurons causing significant altercations in synaptic plasticity. Synaptic plasticity alterations during HIV infection and recreational drug abuse are mediated by complex cellular phenomena involving change …
Neurological illnesses weaken the connections between neurons causing significant altercations in synaptic plasticity. Synaptic pl …
Prefrontal synaptic markers of cocaine addiction-like behavior in rats.
Mol Psychiatry. 2013 Jun;18(6):729-37. doi: 10.1038/mp.2012.59. Epub 2012 May 15.
Mol Psychiatry. 2013.
PMID: 22584869
Defining the drug-induced neuroadaptations specifically associated with the behavioral manifestation of addiction is a daunting task. ...These data identify specific synaptic impairments in the pPFC associated with addiction and support the idea that alterati …
Defining the drug-induced neuroadaptations specifically associated with the behavioral manifestation of addiction is a dauntin …
Chronic cocaine prevents depotentiation at corticostriatal synapses.
Biol Psychiatry. 2006 Sep 1;60(5):436-43. doi: 10.1016/j.biopsych.2005.11.018. Epub 2006 Feb 14.
Biol Psychiatry. 2006.
PMID: 16476411
BACKGROUND: The advanced stages of addiction are characterized by compulsive drug-seeking and drug-taking behaviors despite the loss of the hedonic effect of drug consumption. A pathology of habit forming systems might underlie these feat …
BACKGROUND: The advanced stages of addiction are characterized by compulsive drug-seeking and drug-taking behavi …
Opioids block long-term potentiation of inhibitory synapses.
Nature. 2007 Apr 26;446(7139):1086-90. doi: 10.1038/nature05726.
Nature. 2007.
PMID: 17460674
Excitatory brain synapses are strengthened or weakened in response to specific patterns of synaptic activation, and these changes in synaptic strength are thought to underlie persistent pathologies such as drug addiction, as well as learning. In contrast, the …
Excitatory brain synapses are strengthened or weakened in response to specific patterns of synaptic activation, and these changes in synapti …
Withdrawal from cocaine self-administration normalizes deficits in proliferation and enhances maturity of adult-generated hippocampal neurons.
J Neurosci. 2008 Mar 5;28(10):2516-26. doi: 10.1523/JNEUROSCI.4661-07.2008.
J Neurosci. 2008.
PMID: 18322096
Free PMC article.
Relapse, a major problem in the treatment of cocaine addiction, is proposed to result in part from neuroadaptations in the hippocampus. ...Rats self-administered intravenous cocaine or saline for 3 weeks and were killed 2 h (CSA) or 4 weeks (CSA-WD, CSA-CONT) after injecti …
Relapse, a major problem in the treatment of cocaine addiction, is proposed to result in part from neuroadaptations in the hippocampu …
EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers.
PLoS One. 2014 Mar 21;9(3):e92309. doi: 10.1371/journal.pone.0092309. eCollection 2014.
PLoS One. 2014.
PMID: 24658113
Free PMC article.
The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity and synapse loss. ...According to this results, the EphA4 antagonistic peptide KYL and c-Abl inhibitor STI prevented i) dendritic spine reduction, ii) the blocking of LTP induc …
The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity and synapse loss. ...According to th …
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