Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.
Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS.
Duan T, et al.
FASEB J. 2019 Oct;33(10):10924-10934. doi: 10.1096/fj.201901166R. Epub 2019 Jul 3.
FASEB J. 2019.
PMID: 31268738
Free PMC article.
These results implicate CFTR activation in the colon as a major prosecretory mechanism of CDCA, a bile acid implicated in BAD, and support the potential therapeutic efficacy of CFTR inhibition in bile acid-associated diarrheas.-Duan, T., Cil, O., Tse, C. M., Sarker, …
These results implicate CFTR activation in the colon as a major prosecretory mechanism of CDCA, a bile acid implicated in BAD, and support t …