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Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury.
Kapitsinou PP, Sano H, Michael M, Kobayashi H, Davidoff O, Bian A, Yao B, Zhang MZ, Harris RC, Duffy KJ, Erickson-Miller CL, Sutton TA, Haase VH. Kapitsinou PP, et al. Among authors: duffy kj. J Clin Invest. 2014 Jun;124(6):2396-409. doi: 10.1172/JCI69073. Epub 2014 May 1. J Clin Invest. 2014. PMID: 24789906 Free PMC article.
Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.
Ariazi JL, Duffy KJ, Adams DF, Fitch DM, Luo L, Pappalardi M, Biju M, DiFilippo EH, Shaw T, Wiggall K, Erickson-Miller C. Ariazi JL, et al. Among authors: duffy kj. J Pharmacol Exp Ther. 2017 Dec;363(3):336-347. doi: 10.1124/jpet.117.242503. Epub 2017 Sep 19. J Pharmacol Exp Ther. 2017. PMID: 28928122
Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.
Bao W, Qin P, Needle S, Erickson-Miller CL, Duffy KJ, Ariazi JL, Zhao S, Olzinski AR, Behm DJ, Pipes GC, Jucker BM, Hu E, Lepore JJ, Willette RN. Bao W, et al. Among authors: duffy kj. J Cardiovasc Pharmacol. 2010 Aug;56(2):147-55. doi: 10.1097/FJC.0b013e3181e2bfef. J Cardiovasc Pharmacol. 2010. PMID: 20714241
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics.
Duffy KJ, Price AT, Delorme E, Dillon SB, Duquenne C, Erickson-Miller C, Giampa L, Huang Y, Keenan RM, Lamb P, Liu N, Miller SG, Rosen J, Shaw AN, Smith H, Wiggall KJ, Zhang L, Luengo JI. Duffy KJ, et al. J Med Chem. 2002 Aug 15;45(17):3576-8. doi: 10.1021/jm0255365. J Med Chem. 2002. PMID: 12166929
Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.
Duffy KJ, Shaw AN, Delorme E, Dillon SB, Erickson-Miller C, Giampa L, Huang Y, Keenan RM, Lamb P, Liu N, Miller SG, Price AT, Rosen J, Smith H, Wiggall KJ, Zhang L, Luengo JI. Duffy KJ, et al. J Med Chem. 2002 Aug 15;45(17):3573-5. doi: 10.1021/jm025535c. J Med Chem. 2002. PMID: 12166928
79 results