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The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.
Flisiak R, Horban A, Gallay P, Bobardt M, Selvarajah S, Wiercinska-Drapalo A, Siwak E, Cielniak I, Higersberger J, Kierkus J, Aeschlimann C, Grosgurin P, Nicolas-Métral V, Dumont JM, Porchet H, Crabbé R, Scalfaro P. Flisiak R, et al. Among authors: dumont jm. Hepatology. 2008 Mar;47(3):817-26. doi: 10.1002/hep.22131. Hepatology. 2008. PMID: 18302285 Clinical Trial.
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.
Ptak RG, Gallay PA, Jochmans D, Halestrap AP, Ruegg UT, Pallansch LA, Bobardt MD, de Béthune MP, Neyts J, De Clercq E, Dumont JM, Scalfaro P, Besseghir K, Wenger RM, Rosenwirth B. Ptak RG, et al. Among authors: dumont jm. Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17. doi: 10.1128/AAC.01324-07. Epub 2008 Jan 22. Antimicrob Agents Chemother. 2008. PMID: 18212100 Free PMC article.
Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice.
Gomez L, Thibault H, Gharib A, Dumont JM, Vuagniaux G, Scalfaro P, Derumeaux G, Ovize M. Gomez L, et al. Among authors: dumont jm. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1654-61. doi: 10.1152/ajpheart.01378.2006. Epub 2007 Jun 8. Am J Physiol Heart Circ Physiol. 2007. PMID: 17557911 Free article.
Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells.
Chatterji U, Bobardt MD, Stanfield R, Ptak RG, Pallansch LA, Ward PA, Jones MJ, Stoddart CA, Scalfaro P, Dumont JM, Besseghir K, Rosenwirth B, Gallay PA. Chatterji U, et al. Among authors: dumont jm. J Biol Chem. 2005 Dec 2;280(48):40293-300. doi: 10.1074/jbc.M506314200. Epub 2005 Sep 30. J Biol Chem. 2005. PMID: 16199531 Free article.
Cyclophilin inhibitors in hepatitis C viral infection.
Flisiak R, Dumont JM, Crabbé R. Flisiak R, et al. Among authors: dumont jm. Expert Opin Investig Drugs. 2007 Sep;16(9):1345-54. doi: 10.1517/13543784.16.9.1345. Expert Opin Investig Drugs. 2007. PMID: 17714021 Review.
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors.
Coelmont L, Kaptein S, Paeshuyse J, Vliegen I, Dumont JM, Vuagniaux G, Neyts J. Coelmont L, et al. Among authors: dumont jm. Antimicrob Agents Chemother. 2009 Mar;53(3):967-76. doi: 10.1128/AAC.00939-08. Epub 2008 Dec 22. Antimicrob Agents Chemother. 2009. PMID: 19104013 Free PMC article.
37 results