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A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. Dusonchet J, et al. Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2. Hum Mol Genet. 2014. PMID: 24794857 Free PMC article.
Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate.
Mestre-Francés N, Serratrice N, Gennetier A, Devau G, Cobo S, Trouche SG, Fontès P, Zussy C, De Deurwaerdere P, Salinas S, Mennechet FJ, Dusonchet J, Schneider BL, Saggio I, Kalatzis V, Luquin-Piudo MR, Verdier JM, Kremer EJ. Mestre-Francés N, et al. Among authors: dusonchet j. JCI Insight. 2018 Jul 26;3(14):e98202. doi: 10.1172/jci.insight.98202. eCollection 2018 Jul 26. JCI Insight. 2018. PMID: 30046008 Free PMC article.
Interaction of LRRK2 with kinase and GTPase signaling cascades.
Boon JY, Dusonchet J, Trengrove C, Wolozin B. Boon JY, et al. Among authors: dusonchet j. Front Mol Neurosci. 2014 Jul 9;7:64. doi: 10.3389/fnmol.2014.00064. eCollection 2014. Front Mol Neurosci. 2014. PMID: 25071441 Free PMC article. Review.